Neutrophils kill pathogens by phagocytosis and phagolysosomal fusion. However, activated neutrophils can also form extracellular fibres called neutrophil extracellular traps (NETs), which contain granule proteins and chromatin. These NETs degrade virulence factors and kill bacteria. This study shows that NETs also kill Candida albicans, a eukaryotic pathogen. C. albicans is a common cause of fungal infections, particularly in immunocompromised individuals. It can switch between yeast and hyphal forms. The study demonstrates that NETs kill both yeast and hyphal forms of C. albicans. Granule components mediate fungal killing. NETs trap and kill C. albicans by binding to its cell wall. Histones, a component of NETs, do not kill C. albicans, while granule proteins, such as neutrophil elastase, do. These findings suggest that neutrophils trap and kill ascomycetous yeasts by forming NETs. The study also shows that NETs are effective in killing C. albicans, even when the pathogen is too large to be engulfed by a single neutrophil. This highlights the importance of NETs in controlling fungal infections.Neutrophils kill pathogens by phagocytosis and phagolysosomal fusion. However, activated neutrophils can also form extracellular fibres called neutrophil extracellular traps (NETs), which contain granule proteins and chromatin. These NETs degrade virulence factors and kill bacteria. This study shows that NETs also kill Candida albicans, a eukaryotic pathogen. C. albicans is a common cause of fungal infections, particularly in immunocompromised individuals. It can switch between yeast and hyphal forms. The study demonstrates that NETs kill both yeast and hyphal forms of C. albicans. Granule components mediate fungal killing. NETs trap and kill C. albicans by binding to its cell wall. Histones, a component of NETs, do not kill C. albicans, while granule proteins, such as neutrophil elastase, do. These findings suggest that neutrophils trap and kill ascomycetous yeasts by forming NETs. The study also shows that NETs are effective in killing C. albicans, even when the pathogen is too large to be engulfed by a single neutrophil. This highlights the importance of NETs in controlling fungal infections.