The article discusses the role of neutrophil extracellular traps (NETs) in the pathogenesis of COVID-19-related acute respiratory distress syndrome (ARDS). The study, conducted by researchers from the University of Utah and other institutions, found that NETs contribute to microthrombi formation through interactions between platelets and neutrophils in COVID-19 patients. The researchers observed increased levels of NETs in plasma from COVID-19 patients, particularly those who required intubation and those who died from the disease. They also found that NETs correlated with disease severity, as measured by the PaO2/FiO2 ratio and the Sequential Organ Failure Assessment (SOFA) score. Autopsy samples from three COVID-19 patients showed evidence of NETs and platelet infiltration in the lungs, suggesting that NETs may play a significant role in the development of microthrombi and lung injury. The study also demonstrated that neonatal NET-inhibitory factor (nNIF) blocked NET formation induced by COVID-19 plasma, indicating a potential therapeutic target for reducing immunothrombosis in COVID-19. The findings highlight the importance of NETs in the clinical manifestations of severe COVID-19 and suggest that targeting NETs could be a promising approach for managing the disease.The article discusses the role of neutrophil extracellular traps (NETs) in the pathogenesis of COVID-19-related acute respiratory distress syndrome (ARDS). The study, conducted by researchers from the University of Utah and other institutions, found that NETs contribute to microthrombi formation through interactions between platelets and neutrophils in COVID-19 patients. The researchers observed increased levels of NETs in plasma from COVID-19 patients, particularly those who required intubation and those who died from the disease. They also found that NETs correlated with disease severity, as measured by the PaO2/FiO2 ratio and the Sequential Organ Failure Assessment (SOFA) score. Autopsy samples from three COVID-19 patients showed evidence of NETs and platelet infiltration in the lungs, suggesting that NETs may play a significant role in the development of microthrombi and lung injury. The study also demonstrated that neonatal NET-inhibitory factor (nNIF) blocked NET formation induced by COVID-19 plasma, indicating a potential therapeutic target for reducing immunothrombosis in COVID-19. The findings highlight the importance of NETs in the clinical manifestations of severe COVID-19 and suggest that targeting NETs could be a promising approach for managing the disease.