This study investigates the role of neutrophil extracellular traps (NETs) in the metastasis of circulating tumor cells (CTCs) during systemic infection. The authors found that NETs trap CTCs in both static and dynamic conditions, leading to increased hepatic micrometastases and gross metastatic disease burden. This effect was mitigated by inhibiting NET formation with DNase or a neutrophil elastase inhibitor. The findings suggest that NETs play a crucial role in cancer metastasis in the context of systemic infection and identify them as potential therapeutic targets.This study investigates the role of neutrophil extracellular traps (NETs) in the metastasis of circulating tumor cells (CTCs) during systemic infection. The authors found that NETs trap CTCs in both static and dynamic conditions, leading to increased hepatic micrometastases and gross metastatic disease burden. This effect was mitigated by inhibiting NET formation with DNase or a neutrophil elastase inhibitor. The findings suggest that NETs play a crucial role in cancer metastasis in the context of systemic infection and identify them as potential therapeutic targets.