New insights into cancer immunoediting and its three component phases — elimination, equilibrium and escape

New insights into cancer immunoediting and its three component phases — elimination, equilibrium and escape

2014 April | Deepak Mittal, Matthew M Gubin, Robert D Schreiber, and Mark J Smyth
The article discusses the three phases of cancer immunoediting: elimination, equilibrium, and escape. Immunoediting is the process by which the immune system shapes tumor development and can either eliminate or allow the survival of cancer cells. In the elimination phase, the immune system destroys early tumors before they become clinically apparent. This phase is driven by both innate and adaptive immune mechanisms, including the recognition of tumor antigens and the activation of immune cells such as T cells, NK cells, and macrophages. In the equilibrium phase, the immune system maintains a balance between anti-tumor and tumor-promoting factors, allowing some tumor cells to survive and evolve. This phase is characterized by the presence of immune cells such as CD8+ T cells, NK cells, and γδ T cells, which help maintain tumor dormancy. In the escape phase, the tumor cells evade immune recognition and develop mechanisms to suppress the immune system, leading to the progression of cancer. The article highlights the importance of understanding these phases in developing effective cancer immunotherapies. It also discusses the role of immune cells in tumor progression and the potential for targeting immune checkpoints to enhance the effectiveness of immunotherapy. The study emphasizes the need for personalized approaches to cancer treatment based on the immune status of the tumor and the patient.The article discusses the three phases of cancer immunoediting: elimination, equilibrium, and escape. Immunoediting is the process by which the immune system shapes tumor development and can either eliminate or allow the survival of cancer cells. In the elimination phase, the immune system destroys early tumors before they become clinically apparent. This phase is driven by both innate and adaptive immune mechanisms, including the recognition of tumor antigens and the activation of immune cells such as T cells, NK cells, and macrophages. In the equilibrium phase, the immune system maintains a balance between anti-tumor and tumor-promoting factors, allowing some tumor cells to survive and evolve. This phase is characterized by the presence of immune cells such as CD8+ T cells, NK cells, and γδ T cells, which help maintain tumor dormancy. In the escape phase, the tumor cells evade immune recognition and develop mechanisms to suppress the immune system, leading to the progression of cancer. The article highlights the importance of understanding these phases in developing effective cancer immunotherapies. It also discusses the role of immune cells in tumor progression and the potential for targeting immune checkpoints to enhance the effectiveness of immunotherapy. The study emphasizes the need for personalized approaches to cancer treatment based on the immune status of the tumor and the patient.
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Understanding New insights into cancer immunoediting and its three component phases--elimination%2C equilibrium and escape.