New microRNAs from mouse and human

New microRNAs from mouse and human

2003 | MARIANA LAGOS-QUINTANA, REINHARD RAUHUT, JUTTA MEYER, ARNDT BORKHARDT, THOMAS TUSCHL
This study reports the identification of 31 novel microRNAs (miRNAs) from mouse tissues and the human Saos-2 cell line. The miRNAs were cloned and characterized, with 91% of the identified sequences matching previously known miRNAs. The newly identified miRNAs are discussed, particularly those that are conserved across different vertebrate species. The authors highlight the importance of miRNAs in regulating gene expression and their potential roles in various biological processes. They also note that the identification of miRNAs has reached a practical limit using conventional cloning methods, suggesting that further insights into miRNA function may require alternative approaches. The study emphasizes the significance of comprehensive miRNA collections for functional analysis and genome annotation.This study reports the identification of 31 novel microRNAs (miRNAs) from mouse tissues and the human Saos-2 cell line. The miRNAs were cloned and characterized, with 91% of the identified sequences matching previously known miRNAs. The newly identified miRNAs are discussed, particularly those that are conserved across different vertebrate species. The authors highlight the importance of miRNAs in regulating gene expression and their potential roles in various biological processes. They also note that the identification of miRNAs has reached a practical limit using conventional cloning methods, suggesting that further insights into miRNA function may require alternative approaches. The study emphasizes the significance of comprehensive miRNA collections for functional analysis and genome annotation.
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