Nipype is an open-source, community-developed Python-based software package designed to address the challenges in neuroimaging data processing. It provides a flexible, lightweight, and extensible framework for interacting with existing neuroimaging software, facilitating the creation of workflows and enabling efficient, reproducible, and comparative algorithm development. Nipype standardizes access to various neuroimaging tools, supports uniform usage semantics, and allows for the integration of different software packages. It includes interfaces for popular neuroimaging software such as SPM, FSL, and FreeSurfer, and supports both local and remote execution on multi-core machines and clusters. Nipype also offers features like parameter space exploration, workflow visualization, and configuration options for optimizing execution efficiency. The software is distributed under a BSD license, allowing unrestricted use and community-driven development, making it a valuable tool for neuroimaging researchers and practitioners.Nipype is an open-source, community-developed Python-based software package designed to address the challenges in neuroimaging data processing. It provides a flexible, lightweight, and extensible framework for interacting with existing neuroimaging software, facilitating the creation of workflows and enabling efficient, reproducible, and comparative algorithm development. Nipype standardizes access to various neuroimaging tools, supports uniform usage semantics, and allows for the integration of different software packages. It includes interfaces for popular neuroimaging software such as SPM, FSL, and FreeSurfer, and supports both local and remote execution on multi-core machines and clusters. Nipype also offers features like parameter space exploration, workflow visualization, and configuration options for optimizing execution efficiency. The software is distributed under a BSD license, allowing unrestricted use and community-driven development, making it a valuable tool for neuroimaging researchers and practitioners.