The article "Non-coding RNA networks in cancer" by Eleni Anastasiadou, Leni S. Jacob, and Frank J. Slack reviews the role of non-coding RNAs (ncRNAs) in cancer. It highlights that ncRNAs, which were once considered 'junk' transcriptional products, are now recognized as functional regulatory molecules involved in various cellular processes. The authors discuss how ncRNAs form complex networks that influence numerous molecular targets, driving specific cell biological responses and fates. They emphasize that ncRNAs act as key regulators in developmental and disease contexts, particularly in cancer, where they have been identified as both oncogenic drivers and tumor suppressors. The review covers the evolution of understanding ncRNAs, from their initial discovery in *Caenorhabditis elegans* to the current landscape of ncRNA species, including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs). It explains the complex interactions within these networks, such as feedback loops and feedforward loops, and how these interactions contribute to malignant phenotypes. The authors also discuss the context-dependent roles of ncRNAs, where the same ncRNA can have different functions in different cancer types. The article further explores the concept of "supergenes," where a single gene locus can produce multiple ncRNA products, each with distinct functions. Examples include the ASCC3 locus, which can generate either a protein or an lncRNA, and the *H19* locus, which encodes multiple ncRNAs and proteins. These supergenes provide a mechanism for fine-tuning cellular responses and may offer therapeutic targets. Additionally, the review examines other patterns of ncRNA interactions, such as regulation of protein complexes and competitive interactions through sponging. It highlights the role of ncRNAs in recruiting chromatin-modifying complexes and sequestering miRNAs or proteins to alter gene expression and cellular processes. Finally, the authors discuss the disruption of ncRNA networks in cancer, including genomic alterations that lead to the formation of fusion ncRNAs and changes in adenosine-to-inosine editing that alter miRNA targeting. They emphasize the importance of understanding these complex networks for the development of more effective cancer treatments.The article "Non-coding RNA networks in cancer" by Eleni Anastasiadou, Leni S. Jacob, and Frank J. Slack reviews the role of non-coding RNAs (ncRNAs) in cancer. It highlights that ncRNAs, which were once considered 'junk' transcriptional products, are now recognized as functional regulatory molecules involved in various cellular processes. The authors discuss how ncRNAs form complex networks that influence numerous molecular targets, driving specific cell biological responses and fates. They emphasize that ncRNAs act as key regulators in developmental and disease contexts, particularly in cancer, where they have been identified as both oncogenic drivers and tumor suppressors. The review covers the evolution of understanding ncRNAs, from their initial discovery in *Caenorhabditis elegans* to the current landscape of ncRNA species, including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs). It explains the complex interactions within these networks, such as feedback loops and feedforward loops, and how these interactions contribute to malignant phenotypes. The authors also discuss the context-dependent roles of ncRNAs, where the same ncRNA can have different functions in different cancer types. The article further explores the concept of "supergenes," where a single gene locus can produce multiple ncRNA products, each with distinct functions. Examples include the ASCC3 locus, which can generate either a protein or an lncRNA, and the *H19* locus, which encodes multiple ncRNAs and proteins. These supergenes provide a mechanism for fine-tuning cellular responses and may offer therapeutic targets. Additionally, the review examines other patterns of ncRNA interactions, such as regulation of protein complexes and competitive interactions through sponging. It highlights the role of ncRNAs in recruiting chromatin-modifying complexes and sequestering miRNAs or proteins to alter gene expression and cellular processes. Finally, the authors discuss the disruption of ncRNA networks in cancer, including genomic alterations that lead to the formation of fusion ncRNAs and changes in adenosine-to-inosine editing that alter miRNA targeting. They emphasize the importance of understanding these complex networks for the development of more effective cancer treatments.