This review discusses the role of microRNAs (miRNAs) in regulating neuroinflammation and their implications for neurological disorders. Neuroinflammation, a balanced inflammatory response, can become chronic and lead to tissue damage. MiRNAs are master regulators that control inflammatory responses, affecting the activity of cytokines, chemokines, and reactive oxygen species. They play a crucial role in modulating the activity of interleukins, TGF-B, NF-kB, and toll-like receptor signaling, which are linked to various neurological disorders such as Parkinson's, ALS, epilepsy, Alzheimer's, and neuromuscular degeneration. The review highlights the importance of understanding miRNA regulation of microglial activation to develop therapeutic interventions for chronic neurological disorders. MiRNAs are also discussed in the context of epilepsy and ALS, where their dysregulation contributes to disease progression and where they may serve as therapeutic targets. The review emphasizes the need for further research to elucidate the mechanisms by which miRNAs regulate neuroinflammation and to develop miRNA-based therapies for these disorders.This review discusses the role of microRNAs (miRNAs) in regulating neuroinflammation and their implications for neurological disorders. Neuroinflammation, a balanced inflammatory response, can become chronic and lead to tissue damage. MiRNAs are master regulators that control inflammatory responses, affecting the activity of cytokines, chemokines, and reactive oxygen species. They play a crucial role in modulating the activity of interleukins, TGF-B, NF-kB, and toll-like receptor signaling, which are linked to various neurological disorders such as Parkinson's, ALS, epilepsy, Alzheimer's, and neuromuscular degeneration. The review highlights the importance of understanding miRNA regulation of microglial activation to develop therapeutic interventions for chronic neurological disorders. MiRNAs are also discussed in the context of epilepsy and ALS, where their dysregulation contributes to disease progression and where they may serve as therapeutic targets. The review emphasizes the need for further research to elucidate the mechanisms by which miRNAs regulate neuroinflammation and to develop miRNA-based therapies for these disorders.