This paper explores the use of single-walled carbon nanotubes (SWNTs) as a platform for developing highly specific electronic biosensors. The authors address the issue of nonspecific binding (NSB) of proteins to SWNTs, which is a common problem in biosensing applications. They demonstrate that polyethylene oxide (PEO) chains can be immobilized on SWNTs to prevent NSB while enabling the selective recognition and binding of target proteins. This approach, combined with the sensitivity of nanotube electronic devices, allows for the detection of clinically important biomolecules such as antibodies associated with autoimmune diseases. The study uses atomic force microscopy (AFM), quartz crystal microbalance (QCM), and electronic transport measurements to characterize the interactions between proteins and SWNTs. The results show that PEO-functionalized SWNTs exhibit excellent resistance to NSB and can be used to detect specific protein interactions without the need for labeling. The authors also demonstrate the practical application of these biosensors by detecting the binding of monoclonal antibodies to a recombinant human autoantigen, U1A, which is relevant for diagnosing autoimmune diseases. The work highlights the potential of SWNT-based biosensors for disease diagnosis and proteomics applications.This paper explores the use of single-walled carbon nanotubes (SWNTs) as a platform for developing highly specific electronic biosensors. The authors address the issue of nonspecific binding (NSB) of proteins to SWNTs, which is a common problem in biosensing applications. They demonstrate that polyethylene oxide (PEO) chains can be immobilized on SWNTs to prevent NSB while enabling the selective recognition and binding of target proteins. This approach, combined with the sensitivity of nanotube electronic devices, allows for the detection of clinically important biomolecules such as antibodies associated with autoimmune diseases. The study uses atomic force microscopy (AFM), quartz crystal microbalance (QCM), and electronic transport measurements to characterize the interactions between proteins and SWNTs. The results show that PEO-functionalized SWNTs exhibit excellent resistance to NSB and can be used to detect specific protein interactions without the need for labeling. The authors also demonstrate the practical application of these biosensors by detecting the binding of monoclonal antibodies to a recombinant human autoantigen, U1A, which is relevant for diagnosing autoimmune diseases. The work highlights the potential of SWNT-based biosensors for disease diagnosis and proteomics applications.