This study investigates the potential of low-intensity transcranial focused ultrasound to modulate deep brain circuits in humans, specifically targeting the ventral intermediate nucleus (VIM) of the thalamus in patients with essential tremor. The researchers applied brief, 15-second stimulations of the VIM at a 10% duty cycle, repeated less than 30 times over a 90-minute period. The results showed that this approach significantly reduced tremor amplitude in two out of three patients, with reductions of up to 98% and 97%. The effect was observed within seconds of stimulation and gradually faded, indicating safety and no long-term side effects. The study demonstrates that low-intensity focused ultrasound can robustly modulate deep brain regions, providing a new tool for understanding and treating neurological disorders.This study investigates the potential of low-intensity transcranial focused ultrasound to modulate deep brain circuits in humans, specifically targeting the ventral intermediate nucleus (VIM) of the thalamus in patients with essential tremor. The researchers applied brief, 15-second stimulations of the VIM at a 10% duty cycle, repeated less than 30 times over a 90-minute period. The results showed that this approach significantly reduced tremor amplitude in two out of three patients, with reductions of up to 98% and 97%. The effect was observed within seconds of stimulation and gradually faded, indicating safety and no long-term side effects. The study demonstrates that low-intensity focused ultrasound can robustly modulate deep brain regions, providing a new tool for understanding and treating neurological disorders.