The DAVID Bioinformatics Resources have been updated to provide enhanced functional interpretation of large gene lists from genomic studies. The new DAVID Knowledgebase integrates over 20 types of gene/protein identifiers and more than 40 functional annotation categories from public databases, using a single-linkage method to group tens of millions of identifiers and annotations. This allows for more comprehensive gene-term enrichment analysis and new tools to condense gene lists into functional groups, convert identifiers, visualize gene-term relationships, and cluster redundant terms. The DAVID Functional Annotation Tool Suite includes tools for gene-term enrichment analysis, clustering annotation terms, and visualizing genes on pathways. The DAVID Gene Functional Classification Tool uses fuzzy algorithms to classify genes into functional groups based on annotation term co-occurrence. The DAVID Gene ID Conversion Tool enables conversion between gene identifiers across multiple systems. The DAVID Gene Name Batch Viewer provides gene names and links for further exploration. The DAVID NIAID Pathogen Browser helps researchers search genes in priority pathogens. The DAVID API Services allow direct integration with other bioinformatics tools. The updated DAVID Bioinformatics Resources offer powerful tools for exploring gene lists from multiple biological angles, enhancing the ability to extract biological meaning. The DAVID Knowledgebase is freely available to the public, promoting the development of new annotation algorithms. The resources are accessible at http://david.niaid.nih.gov.The DAVID Bioinformatics Resources have been updated to provide enhanced functional interpretation of large gene lists from genomic studies. The new DAVID Knowledgebase integrates over 20 types of gene/protein identifiers and more than 40 functional annotation categories from public databases, using a single-linkage method to group tens of millions of identifiers and annotations. This allows for more comprehensive gene-term enrichment analysis and new tools to condense gene lists into functional groups, convert identifiers, visualize gene-term relationships, and cluster redundant terms. The DAVID Functional Annotation Tool Suite includes tools for gene-term enrichment analysis, clustering annotation terms, and visualizing genes on pathways. The DAVID Gene Functional Classification Tool uses fuzzy algorithms to classify genes into functional groups based on annotation term co-occurrence. The DAVID Gene ID Conversion Tool enables conversion between gene identifiers across multiple systems. The DAVID Gene Name Batch Viewer provides gene names and links for further exploration. The DAVID NIAID Pathogen Browser helps researchers search genes in priority pathogens. The DAVID API Services allow direct integration with other bioinformatics tools. The updated DAVID Bioinformatics Resources offer powerful tools for exploring gene lists from multiple biological angles, enhancing the ability to extract biological meaning. The DAVID Knowledgebase is freely available to the public, promoting the development of new annotation algorithms. The resources are accessible at http://david.niaid.nih.gov.