This scoping review examines the scientific evidence on nurses' well-being at work in hospital settings. The review aims to identify factors influencing nurses' well-being and the role of nurse managers in promoting it. The study followed the Joanna Briggs Institute (JBI) guidelines and used databases such as CINAHL, MEDLINE, Scopus, and others. Eight studies were included, all focusing on the assessment of well-being and manager intervention. The findings indicate that most nurses are satisfied with their work, but several factors, including interaction with management, organizational culture, and commitment, influence their well-being. Nurse managers play a crucial role in creating a positive work environment, which is essential for maintaining and enhancing nurses' well-being. The review highlights the need for further research to deepen understanding and inform evidence-based practices to improve nurse well-being and patient care.This scoping review examines the scientific evidence on nurses' well-being at work in hospital settings. The review aims to identify factors influencing nurses' well-being and the role of nurse managers in promoting it. The study followed the Joanna Briggs Institute (JBI) guidelines and used databases such as CINAHL, MEDLINE, Scopus, and others. Eight studies were included, all focusing on the assessment of well-being and manager intervention. The findings indicate that most nurses are satisfied with their work, but several factors, including interaction with management, organizational culture, and commitment, influence their well-being. Nurse managers play a crucial role in creating a positive work environment, which is essential for maintaining and enhancing nurses' well-being. The review highlights the need for further research to deepen understanding and inform evidence-based practices to improve nurse well-being and patient care.