This study investigates the challenges faced by nurses in disaster response, using a qualitative content analysis approach. The study involved 24 nurses from emergency departments in Kerman, Iran, through semi-structured interviews. The main theme identified was the insufficient ability of nurses to respond to disasters, encompassing five subcategories: diverse nursing conditions during disasters, inappropriate interactive platforms, obstacles to teamwork, lack of platforms for acquiring disaster risk management competence, and moral tension in complex disaster situations. Nurses reported experiencing confusion, uncertainty, and prolonged exposure to chaotic environments, leading to physical and mental vulnerabilities. They also faced difficulties in communication, teamwork, and receiving adequate support from managers. The study highlights the need for continuous training, better leadership, and improved disaster risk management systems to enhance nurses' preparedness and effectiveness in disaster response.This study investigates the challenges faced by nurses in disaster response, using a qualitative content analysis approach. The study involved 24 nurses from emergency departments in Kerman, Iran, through semi-structured interviews. The main theme identified was the insufficient ability of nurses to respond to disasters, encompassing five subcategories: diverse nursing conditions during disasters, inappropriate interactive platforms, obstacles to teamwork, lack of platforms for acquiring disaster risk management competence, and moral tension in complex disaster situations. Nurses reported experiencing confusion, uncertainty, and prolonged exposure to chaotic environments, leading to physical and mental vulnerabilities. They also faced difficulties in communication, teamwork, and receiving adequate support from managers. The study highlights the need for continuous training, better leadership, and improved disaster risk management systems to enhance nurses' preparedness and effectiveness in disaster response.