The OARSI guidelines for the non-surgical management of knee osteoarthritis (OA) provide evidence-based recommendations for the treatment of knee OA, focusing on patient-centered, clinically relevant interventions. The guidelines were developed by an international panel of 13 experts from various medical disciplines, including rheumatology, orthopedics, physical therapy, and primary care, along with a patient representative. The guidelines were based on a systematic review of the literature published between 2009 and 2013, and were evaluated using the RAND/UCLA Appropriateness Method and Delphi voting process. The recommendations were stratified into four clinical sub-phenotypes based on the presence of co-morbidities and the extent of OA burden. The guidelines recommend biomechanical interventions, intra-articular corticosteroids, exercise (land-based and water-based), self-management and education, strength training, and weight management as appropriate treatments for all individuals with knee OA. Acetaminophen, balneotherapy, capsaicin, canes, duloxetine, and oral and topical NSAIDs are recommended for specific sub-phenotypes. Treatments such as acupuncture, avocado soybean unsaponifiables, chondroitin, intra-articular hyaluronic acid, opioids, rosehip, and transcutaneous electrical nerve stimulation are classified as uncertain, while risedronate and electrotherapy are not appropriate. The guidelines emphasize the importance of individualized treatment based on patient characteristics, co-morbidities, and preferences. They also highlight the need for further research to clarify the role of certain treatments, particularly those with uncertain appropriateness. The guidelines are intended for use by healthcare professionals worldwide and are based on the relative safety and efficacy of available treatments, regardless of healthcare reimbursement policies or popular treatment practices. The recommendations are supported by high-quality evidence, including meta-analyses, systematic reviews, and randomized controlled trials. The guidelines aim to provide a comprehensive framework for the management of knee OA, ensuring that patients receive appropriate and effective care.The OARSI guidelines for the non-surgical management of knee osteoarthritis (OA) provide evidence-based recommendations for the treatment of knee OA, focusing on patient-centered, clinically relevant interventions. The guidelines were developed by an international panel of 13 experts from various medical disciplines, including rheumatology, orthopedics, physical therapy, and primary care, along with a patient representative. The guidelines were based on a systematic review of the literature published between 2009 and 2013, and were evaluated using the RAND/UCLA Appropriateness Method and Delphi voting process. The recommendations were stratified into four clinical sub-phenotypes based on the presence of co-morbidities and the extent of OA burden. The guidelines recommend biomechanical interventions, intra-articular corticosteroids, exercise (land-based and water-based), self-management and education, strength training, and weight management as appropriate treatments for all individuals with knee OA. Acetaminophen, balneotherapy, capsaicin, canes, duloxetine, and oral and topical NSAIDs are recommended for specific sub-phenotypes. Treatments such as acupuncture, avocado soybean unsaponifiables, chondroitin, intra-articular hyaluronic acid, opioids, rosehip, and transcutaneous electrical nerve stimulation are classified as uncertain, while risedronate and electrotherapy are not appropriate. The guidelines emphasize the importance of individualized treatment based on patient characteristics, co-morbidities, and preferences. They also highlight the need for further research to clarify the role of certain treatments, particularly those with uncertain appropriateness. The guidelines are intended for use by healthcare professionals worldwide and are based on the relative safety and efficacy of available treatments, regardless of healthcare reimbursement policies or popular treatment practices. The recommendations are supported by high-quality evidence, including meta-analyses, systematic reviews, and randomized controlled trials. The guidelines aim to provide a comprehensive framework for the management of knee OA, ensuring that patients receive appropriate and effective care.