The Osteoarthritis Research Society International (OARSI) has updated its guidelines for the non-surgical management of knee osteoarthritis (OA) to provide concise, evidence-based, and patient-focused recommendations. The guidelines were developed by a multidisciplinary expert panel and incorporate recent literature up to March 2013. Treatments were evaluated for appropriateness, benefit, and risk using the RAND/UCLA Appropriateness Method and Delphi voting. Key recommendations include the use of biomechanical interventions, intra-articular corticosteroids, exercise (land-based and water-based), self-management and education, strength training, and weight management for all individuals with knee OA. Specific treatments were recommended as appropriate, uncertain, or not appropriate for different clinical sub-phenotypes, considering co-morbidities and the presence of OA in other joints. The guidelines aim to guide healthcare professionals and patients in optimizing treatment choices for knee OA, reflecting the best available evidence and expert consensus.The Osteoarthritis Research Society International (OARSI) has updated its guidelines for the non-surgical management of knee osteoarthritis (OA) to provide concise, evidence-based, and patient-focused recommendations. The guidelines were developed by a multidisciplinary expert panel and incorporate recent literature up to March 2013. Treatments were evaluated for appropriateness, benefit, and risk using the RAND/UCLA Appropriateness Method and Delphi voting. Key recommendations include the use of biomechanical interventions, intra-articular corticosteroids, exercise (land-based and water-based), self-management and education, strength training, and weight management for all individuals with knee OA. Specific treatments were recommended as appropriate, uncertain, or not appropriate for different clinical sub-phenotypes, considering co-morbidities and the presence of OA in other joints. The guidelines aim to guide healthcare professionals and patients in optimizing treatment choices for knee OA, reflecting the best available evidence and expert consensus.