The article "Obesity and Cancer" by Kathleen Y. Wolin, Kenneth Carson, and Graham A. Colditz reviews the relationship between obesity and various cancers, including esophageal, thyroid, colon, renal, liver, melanoma, multiple myeloma, rectum, gallbladder, leukemia, lymphoma, and prostate in men, and postmenopausal breast and endometrium in women. The authors highlight that obesity accounts for approximately 20% of all cancer cases and discuss the mechanisms underlying this association, such as increased insulin levels and inflammation. They emphasize the importance of weight loss, particularly among postmenopausal women, in reducing breast cancer risk. The article also addresses the impact of obesity on cancer outcomes, noting poor outcomes for obese women with breast cancer and the need for physical activity to improve quality of life and survival. Additionally, it discusses the challenges of dosing chemotherapy and radiation therapy in obese patients and provides guidelines for counseling patients on weight loss and increased physical activity. The authors conclude that obesity is a significant risk factor for cancer and that interventions to reduce obesity can have substantial benefits for cancer prevention and improved outcomes.The article "Obesity and Cancer" by Kathleen Y. Wolin, Kenneth Carson, and Graham A. Colditz reviews the relationship between obesity and various cancers, including esophageal, thyroid, colon, renal, liver, melanoma, multiple myeloma, rectum, gallbladder, leukemia, lymphoma, and prostate in men, and postmenopausal breast and endometrium in women. The authors highlight that obesity accounts for approximately 20% of all cancer cases and discuss the mechanisms underlying this association, such as increased insulin levels and inflammation. They emphasize the importance of weight loss, particularly among postmenopausal women, in reducing breast cancer risk. The article also addresses the impact of obesity on cancer outcomes, noting poor outcomes for obese women with breast cancer and the need for physical activity to improve quality of life and survival. Additionally, it discusses the challenges of dosing chemotherapy and radiation therapy in obese patients and provides guidelines for counseling patients on weight loss and increased physical activity. The authors conclude that obesity is a significant risk factor for cancer and that interventions to reduce obesity can have substantial benefits for cancer prevention and improved outcomes.