Obesity is characterized by the accumulation of excessive fat, which can lead to a pro-inflammatory state and oxidative stress. The excess macronutrients in adipose tissues stimulate the release of inflammatory mediators such as tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), while reducing the production of adiponectin. IL-6, a cytokine produced by various cell types, including immune cells and adipose tissue, plays a crucial role in mediating inflammatory responses. It is particularly important in regulating energy homeostasis and appetite. The link between obesity and inflammation is attributed to the overexpression of pro-inflammatory cytokines in adipose tissue, which can be inhibited by farnesoid X receptor (FXR) activation. C-reactive protein (CRP), synthesized primarily by the liver, is a sensitive marker of systemic inflammation and is associated with increased cardiovascular disease (CVD) risk. Adiponectin, a protein hormone derived from adipocytes, has anti-inflammatory effects and is involved in improving insulin sensitivity and reducing metabolic abnormalities. Reduced levels of adiponectin are associated with increased risk of metabolic syndrome, atherosclerosis, and other diseases. The sustained inflammation caused by obesity can lead to various complications, including CVD, metabolic syndrome, diabetes, and cancer. Managing obesity can help reduce these risks by inhibiting inflammatory mechanisms.Obesity is characterized by the accumulation of excessive fat, which can lead to a pro-inflammatory state and oxidative stress. The excess macronutrients in adipose tissues stimulate the release of inflammatory mediators such as tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), while reducing the production of adiponectin. IL-6, a cytokine produced by various cell types, including immune cells and adipose tissue, plays a crucial role in mediating inflammatory responses. It is particularly important in regulating energy homeostasis and appetite. The link between obesity and inflammation is attributed to the overexpression of pro-inflammatory cytokines in adipose tissue, which can be inhibited by farnesoid X receptor (FXR) activation. C-reactive protein (CRP), synthesized primarily by the liver, is a sensitive marker of systemic inflammation and is associated with increased cardiovascular disease (CVD) risk. Adiponectin, a protein hormone derived from adipocytes, has anti-inflammatory effects and is involved in improving insulin sensitivity and reducing metabolic abnormalities. Reduced levels of adiponectin are associated with increased risk of metabolic syndrome, atherosclerosis, and other diseases. The sustained inflammation caused by obesity can lead to various complications, including CVD, metabolic syndrome, diabetes, and cancer. Managing obesity can help reduce these risks by inhibiting inflammatory mechanisms.