Obesity and overweight in adulthood are strongly associated with reduced life expectancy and increased risk of premature death. A life-table analysis of the Framingham Heart Study (1948–1990) found that 40-year-old nonsmoking women who were obese lost 7.1 years of life expectancy, while 40-year-old nonsmoking men who were obese lost 5.8 years. Obese smokers lost even more, with female smokers losing 13.3 years and male smokers losing 13.7 years compared to normal-weight nonsmokers. Overweight individuals, particularly nonsmoking men and women, also experienced reduced life expectancy, with nonsmoking men losing 3.1 years and women losing 3.3 years compared to normal-weight nonsmokers. The study found that body mass index (BMI) at age 30–49 years predicted mortality after age 50–69 years, even after adjusting for BMI at age 50–69 years. Obesity in adulthood is a strong predictor of death at older ages, with the risk of premature death being similar to that of smoking. The study highlights the importance of addressing obesity as a public health issue, given its significant impact on life expectancy and mortality. The analysis used data from the Framingham Heart Study, a longitudinal study with excellent mortality follow-up. The study found that BMI at baseline was a significant predictor of mortality, with higher BMI groups associated with increased mortality risk. The study also considered the effects of smoking, hypertension, diabetes, and other risk factors. The results suggest that obesity in adulthood is a major contributor to premature mortality and reduced life expectancy, and that prevention and treatment of obesity should be prioritized in public health. The study's findings are consistent with previous research, showing that obesity is a significant risk factor for mortality. The results indicate that the relationship between BMI and mortality is J-shaped, with increased mortality risk associated with both underweight and overweight/obese individuals. However, the study found that the increased mortality risk at very low weights may be due to preexisting illness or inadequate smoking control. The study also found that the effect of BMI on mortality is independent of future BMI changes, suggesting that obesity in adulthood has a direct impact on mortality. The study's results emphasize the need for effective prevention and treatment strategies for obesity, as it is a major public health issue with significant implications for life expectancy and mortality.Obesity and overweight in adulthood are strongly associated with reduced life expectancy and increased risk of premature death. A life-table analysis of the Framingham Heart Study (1948–1990) found that 40-year-old nonsmoking women who were obese lost 7.1 years of life expectancy, while 40-year-old nonsmoking men who were obese lost 5.8 years. Obese smokers lost even more, with female smokers losing 13.3 years and male smokers losing 13.7 years compared to normal-weight nonsmokers. Overweight individuals, particularly nonsmoking men and women, also experienced reduced life expectancy, with nonsmoking men losing 3.1 years and women losing 3.3 years compared to normal-weight nonsmokers. The study found that body mass index (BMI) at age 30–49 years predicted mortality after age 50–69 years, even after adjusting for BMI at age 50–69 years. Obesity in adulthood is a strong predictor of death at older ages, with the risk of premature death being similar to that of smoking. The study highlights the importance of addressing obesity as a public health issue, given its significant impact on life expectancy and mortality. The analysis used data from the Framingham Heart Study, a longitudinal study with excellent mortality follow-up. The study found that BMI at baseline was a significant predictor of mortality, with higher BMI groups associated with increased mortality risk. The study also considered the effects of smoking, hypertension, diabetes, and other risk factors. The results suggest that obesity in adulthood is a major contributor to premature mortality and reduced life expectancy, and that prevention and treatment of obesity should be prioritized in public health. The study's findings are consistent with previous research, showing that obesity is a significant risk factor for mortality. The results indicate that the relationship between BMI and mortality is J-shaped, with increased mortality risk associated with both underweight and overweight/obese individuals. However, the study found that the increased mortality risk at very low weights may be due to preexisting illness or inadequate smoking control. The study also found that the effect of BMI on mortality is independent of future BMI changes, suggesting that obesity in adulthood has a direct impact on mortality. The study's results emphasize the need for effective prevention and treatment strategies for obesity, as it is a major public health issue with significant implications for life expectancy and mortality.