9 September 2010 | Rachel Cooper, Diana Kuh, Rebecca Hardy
This systematic review and meta-analysis examined the associations between objective measures of physical capability (grip strength, walking speed, chair rising, and standing balance) and mortality in community-dwelling populations. The study included published and unpublished data from 25 eligible observational studies. The results showed consistent evidence of associations between all four measures and all-cause mortality. For example, individuals in the weakest quarter of grip strength had a hazard ratio of 1.67 for mortality compared to those in the strongest quarter, after adjusting for age, sex, and body size. Similarly, individuals in the slowest quarter of walking speed had a hazard ratio of 2.87 for mortality. These associations were found in both older and younger populations. The study also found that grip strength was associated with mortality in younger populations, while walking speed, chair rising, and standing balance were primarily studied in older populations. The study concluded that objective measures of physical capability are predictors of all-cause mortality in older community-dwelling populations and may provide useful tools for identifying older people at higher risk of death. The study also found evidence of heterogeneity between studies, but the overall associations remained consistent. The study had some limitations, including the potential for publication bias and the use of proportional hazards assumptions. Despite these limitations, the study provides strong evidence that objective measures of physical capability are associated with mortality in older populations. The study also highlights the need for further research to examine the associations between changes in physical capability with age and mortality, as well as the biological pathways underlying these associations. The study also suggests that more research is needed to determine the value of each additional test once the findings for one test are known. The study concludes that objective measures of physical capability are valuable predictors of mortality in older populations and may be useful tools for identifying individuals at higher risk of death.This systematic review and meta-analysis examined the associations between objective measures of physical capability (grip strength, walking speed, chair rising, and standing balance) and mortality in community-dwelling populations. The study included published and unpublished data from 25 eligible observational studies. The results showed consistent evidence of associations between all four measures and all-cause mortality. For example, individuals in the weakest quarter of grip strength had a hazard ratio of 1.67 for mortality compared to those in the strongest quarter, after adjusting for age, sex, and body size. Similarly, individuals in the slowest quarter of walking speed had a hazard ratio of 2.87 for mortality. These associations were found in both older and younger populations. The study also found that grip strength was associated with mortality in younger populations, while walking speed, chair rising, and standing balance were primarily studied in older populations. The study concluded that objective measures of physical capability are predictors of all-cause mortality in older community-dwelling populations and may provide useful tools for identifying older people at higher risk of death. The study also found evidence of heterogeneity between studies, but the overall associations remained consistent. The study had some limitations, including the potential for publication bias and the use of proportional hazards assumptions. Despite these limitations, the study provides strong evidence that objective measures of physical capability are associated with mortality in older populations. The study also highlights the need for further research to examine the associations between changes in physical capability with age and mortality, as well as the biological pathways underlying these associations. The study also suggests that more research is needed to determine the value of each additional test once the findings for one test are known. The study concludes that objective measures of physical capability are valuable predictors of mortality in older populations and may be useful tools for identifying individuals at higher risk of death.