This article, published in the Journal of Laryngology and Otology in October 1938, presents a study on the pathology of Ménière's syndrome by C. S. Hallpike and H. Cairns. The authors describe the first recorded pathological changes in the temporal bones of two cases of Ménière's syndrome, focusing on the anatomical and histological findings. The paper aims to provide insights into the condition by analyzing the post-mortem changes observed in the temporal bones of the patients. The clinical history of the first case, J.B., a 63-year-old dock laborer, is detailed, including his symptoms of vertigo, progressive deafness, and tinnitus. The surgical intervention involved sectioning the VIIIth nerve, which was complicated by high blood pressure and post-operative complications leading to the patient's death. The pathological report describes the findings in the right temporal bone, noting chronic inflammatory changes in the tympanum, normal labyrinth structures, and moderate post-mortem degeneration of Corti's organ. The study also discusses the saccus endolymphaticus and its surrounding connective tissue, highlighting deviations from the normal structure. The authors conclude that their findings support the hypothesis that Ménière's syndrome may result from a common type of labyrinthine disorder, as proposed by Wright and Crowe. The paper emphasizes the importance of clinical observation in understanding the condition and suggests further research to explore the pathological factors involved.This article, published in the Journal of Laryngology and Otology in October 1938, presents a study on the pathology of Ménière's syndrome by C. S. Hallpike and H. Cairns. The authors describe the first recorded pathological changes in the temporal bones of two cases of Ménière's syndrome, focusing on the anatomical and histological findings. The paper aims to provide insights into the condition by analyzing the post-mortem changes observed in the temporal bones of the patients. The clinical history of the first case, J.B., a 63-year-old dock laborer, is detailed, including his symptoms of vertigo, progressive deafness, and tinnitus. The surgical intervention involved sectioning the VIIIth nerve, which was complicated by high blood pressure and post-operative complications leading to the patient's death. The pathological report describes the findings in the right temporal bone, noting chronic inflammatory changes in the tympanum, normal labyrinth structures, and moderate post-mortem degeneration of Corti's organ. The study also discusses the saccus endolymphaticus and its surrounding connective tissue, highlighting deviations from the normal structure. The authors conclude that their findings support the hypothesis that Ménière's syndrome may result from a common type of labyrinthine disorder, as proposed by Wright and Crowe. The paper emphasizes the importance of clinical observation in understanding the condition and suggests further research to explore the pathological factors involved.