The Journal of Laryngology and Otology (1938) presents a study on the pathological changes in the temporal bones of two patients with Ménière's syndrome. The authors describe for the first time the histological findings in these cases, which were examined post-mortem shortly after surgical intervention for the section of the VIIIth nerve. The paper discusses the surgical factors related to the failure of the operation and the histological changes observed. The study highlights the anatomical relationship between the organs of hearing and balance in the inner ear, and explores possible causes of Ménière's syndrome, including bacterial intoxication, endolymphatic pressure changes, and lesions in the VIIIth nerve. The authors compare their findings with previous reports and conclude that the pathological changes in the two cases align with the view that a significant proportion of Ménière's syndrome cases are due to a common labyrinthine disorder. In Case I, a 63-year-old dock labourer with a history of vertigo and progressive left ear deafness, the post-operative course was complicated by respiratory and neurological issues, leading to death. Autopsy revealed pathological changes in the cerebellum and lungs, as well as degeneration of the organ of Corti and changes in the endolymphatic system. In Case II, a 28-year-old engineer with similar symptoms, the post-operative course was also complicated, resulting in death. Autopsy showed significant endolymphatic dilation, degeneration of the organ of Corti, and changes in the stria vascularis. The authors conclude that the pathological changes observed in both cases are consistent with a form of serous labyrinthitis, possibly due to toxins reaching the inner ear through the round window or via the bloodstream. They also note that some changes may be related to the surgical intervention and resulting meningeal reaction. The study provides detailed histological descriptions of the changes in the temporal bones, including the endolymphatic saccule, cochlea, and vestibular structures. The findings contribute to the understanding of the pathological basis of Ménière's syndrome.The Journal of Laryngology and Otology (1938) presents a study on the pathological changes in the temporal bones of two patients with Ménière's syndrome. The authors describe for the first time the histological findings in these cases, which were examined post-mortem shortly after surgical intervention for the section of the VIIIth nerve. The paper discusses the surgical factors related to the failure of the operation and the histological changes observed. The study highlights the anatomical relationship between the organs of hearing and balance in the inner ear, and explores possible causes of Ménière's syndrome, including bacterial intoxication, endolymphatic pressure changes, and lesions in the VIIIth nerve. The authors compare their findings with previous reports and conclude that the pathological changes in the two cases align with the view that a significant proportion of Ménière's syndrome cases are due to a common labyrinthine disorder. In Case I, a 63-year-old dock labourer with a history of vertigo and progressive left ear deafness, the post-operative course was complicated by respiratory and neurological issues, leading to death. Autopsy revealed pathological changes in the cerebellum and lungs, as well as degeneration of the organ of Corti and changes in the endolymphatic system. In Case II, a 28-year-old engineer with similar symptoms, the post-operative course was also complicated, resulting in death. Autopsy showed significant endolymphatic dilation, degeneration of the organ of Corti, and changes in the stria vascularis. The authors conclude that the pathological changes observed in both cases are consistent with a form of serous labyrinthitis, possibly due to toxins reaching the inner ear through the round window or via the bloodstream. They also note that some changes may be related to the surgical intervention and resulting meningeal reaction. The study provides detailed histological descriptions of the changes in the temporal bones, including the endolymphatic saccule, cochlea, and vestibular structures. The findings contribute to the understanding of the pathological basis of Ménière's syndrome.