A study of 481,688 participants in Taiwan found that prolonged occupational sitting was associated with increased all-cause and cardiovascular disease mortality. Individuals who mostly sat at work had a 16% higher risk of all-cause mortality and a 34% higher risk of cardiovascular disease mortality compared to those who mostly did not sit. However, alternating between sitting and nonsitting at work did not increase mortality risk. For those who mostly sat at work and engaged in low or no leisure-time physical activity (LTPA), increasing LTPA by 15 or 30 minutes per day reduced mortality risk to levels similar to those who mostly did not sit. Individuals with a personal activity intelligence (PAI) score exceeding 100 also experienced a notable reduction in the elevated mortality risk associated with prolonged sitting. The study suggests that reducing prolonged sitting at work and/or increasing daily physical activity can help mitigate the health risks associated with prolonged occupational sitting. The findings highlight the importance of addressing prolonged sitting as part of modern lifestyles, similar to how smoking has been denormalized. The study also emphasizes the need for workplace changes to reduce the negative health impacts of prolonged sitting.A study of 481,688 participants in Taiwan found that prolonged occupational sitting was associated with increased all-cause and cardiovascular disease mortality. Individuals who mostly sat at work had a 16% higher risk of all-cause mortality and a 34% higher risk of cardiovascular disease mortality compared to those who mostly did not sit. However, alternating between sitting and nonsitting at work did not increase mortality risk. For those who mostly sat at work and engaged in low or no leisure-time physical activity (LTPA), increasing LTPA by 15 or 30 minutes per day reduced mortality risk to levels similar to those who mostly did not sit. Individuals with a personal activity intelligence (PAI) score exceeding 100 also experienced a notable reduction in the elevated mortality risk associated with prolonged sitting. The study suggests that reducing prolonged sitting at work and/or increasing daily physical activity can help mitigate the health risks associated with prolonged occupational sitting. The findings highlight the importance of addressing prolonged sitting as part of modern lifestyles, similar to how smoking has been denormalized. The study also emphasizes the need for workplace changes to reduce the negative health impacts of prolonged sitting.