Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), play a significant role in modulating inflammatory processes. These fatty acids can alter the composition of cell membranes, influencing membrane fluidity, cell signaling, and the production of lipid mediators. Inflammatory cells, such as neutrophils, macrophages, and monocytes, typically contain high levels of arachidonic acid (an n-6 fatty acid), but EPA and DHA can reduce this and increase the production of anti-inflammatory lipid mediators like resolvins. These resolvins help resolve inflammation and prevent excessive tissue damage. Additionally, EPA and DHA can decrease the production of pro-inflammatory eicosanoids and cytokines, reduce chemotaxis of leukocytes, and lower the expression of adhesion molecules, which are crucial for immune cell interactions. Marine n-3 PUFAs also influence transcription factors like NF-κB and PPAR-γ, which regulate inflammatory gene expression. The anti-inflammatory effects of marine n-3 PUFAs suggest their potential as therapeutic agents in inflammatory disorders. However, the exact mechanisms and optimal dosages for different conditions require further study. Overall, the fatty acid composition of inflammatory cells significantly influences their function, with EPA and DHA playing a key role in reducing inflammation and promoting resolution.Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), play a significant role in modulating inflammatory processes. These fatty acids can alter the composition of cell membranes, influencing membrane fluidity, cell signaling, and the production of lipid mediators. Inflammatory cells, such as neutrophils, macrophages, and monocytes, typically contain high levels of arachidonic acid (an n-6 fatty acid), but EPA and DHA can reduce this and increase the production of anti-inflammatory lipid mediators like resolvins. These resolvins help resolve inflammation and prevent excessive tissue damage. Additionally, EPA and DHA can decrease the production of pro-inflammatory eicosanoids and cytokines, reduce chemotaxis of leukocytes, and lower the expression of adhesion molecules, which are crucial for immune cell interactions. Marine n-3 PUFAs also influence transcription factors like NF-κB and PPAR-γ, which regulate inflammatory gene expression. The anti-inflammatory effects of marine n-3 PUFAs suggest their potential as therapeutic agents in inflammatory disorders. However, the exact mechanisms and optimal dosages for different conditions require further study. Overall, the fatty acid composition of inflammatory cells significantly influences their function, with EPA and DHA playing a key role in reducing inflammation and promoting resolution.