The article provides a comprehensive overview of the classification methods for long non-coding RNAs (lncRNAs) based on their genomic location and context, effects on DNA sequences, mechanisms of functioning, and targeting mechanisms. LncRNAs are categorized into intergenic, intronic, sense, and antisense types, each with distinct characteristics and functions. The effects of lncRNAs on DNA sequences are classified into cis-acting and trans-acting lncRNAs, which regulate gene expression in close proximity or distant locations, respectively. Mechanisms of functioning include transcriptional regulation, post-transcriptional regulation, and other functions such as protein localization and telomere replication. Targeting mechanisms involve signal, decoy, guide, and scaffold roles, with some lncRNAs exhibiting multiple archetypes. The article highlights the importance of these classifications for understanding lncRNA functions and suggests further research directions, including the exploration of specific groups of lncRNAs and their regulatory networks.The article provides a comprehensive overview of the classification methods for long non-coding RNAs (lncRNAs) based on their genomic location and context, effects on DNA sequences, mechanisms of functioning, and targeting mechanisms. LncRNAs are categorized into intergenic, intronic, sense, and antisense types, each with distinct characteristics and functions. The effects of lncRNAs on DNA sequences are classified into cis-acting and trans-acting lncRNAs, which regulate gene expression in close proximity or distant locations, respectively. Mechanisms of functioning include transcriptional regulation, post-transcriptional regulation, and other functions such as protein localization and telomere replication. Targeting mechanisms involve signal, decoy, guide, and scaffold roles, with some lncRNAs exhibiting multiple archetypes. The article highlights the importance of these classifications for understanding lncRNA functions and suggests further research directions, including the exploration of specific groups of lncRNAs and their regulatory networks.