The article "One Juliet and Four Romeos: VeA and its methyltransferases" by Özlem Sarıkaya-Bayram, Jonathan M. Palmer, Nancy Keller, Gerhard H. Braus, and Özgür Bayram, published in Frontiers in Microbiology, reviews the role of the velvet complex and associated methyltransferases in fungal secondary metabolism and development. The velvet complex, consisting of VeA, VeB, and LaeA, plays a crucial role in coordinating fungal development with secondary metabolite (SM) production. LaeA, a methyltransferase, is essential for the regulation of many SM clusters and is involved in fungal development. Recent studies have identified three additional methyltransferases, LmF, VipC, and VapB, that interact with VeA, forming a complex that influences SM production and fungal development. The article discusses the molecular mechanisms underlying these interactions and their implications for fungal biology, highlighting the complexity and dynamic nature of the VeA supercomplex. The authors conclude that understanding the intricate regulatory networks involving VeA and its methyltransferase partners is crucial for advancing our knowledge of fungal SM production and development, with potential applications in medicine, agriculture, and biotechnology.The article "One Juliet and Four Romeos: VeA and its methyltransferases" by Özlem Sarıkaya-Bayram, Jonathan M. Palmer, Nancy Keller, Gerhard H. Braus, and Özgür Bayram, published in Frontiers in Microbiology, reviews the role of the velvet complex and associated methyltransferases in fungal secondary metabolism and development. The velvet complex, consisting of VeA, VeB, and LaeA, plays a crucial role in coordinating fungal development with secondary metabolite (SM) production. LaeA, a methyltransferase, is essential for the regulation of many SM clusters and is involved in fungal development. Recent studies have identified three additional methyltransferases, LmF, VipC, and VapB, that interact with VeA, forming a complex that influences SM production and fungal development. The article discusses the molecular mechanisms underlying these interactions and their implications for fungal biology, highlighting the complexity and dynamic nature of the VeA supercomplex. The authors conclude that understanding the intricate regulatory networks involving VeA and its methyltransferase partners is crucial for advancing our knowledge of fungal SM production and development, with potential applications in medicine, agriculture, and biotechnology.