Fungal secondary metabolism is a key area of research with significant biomedical and biotechnological importance. The study highlights the role of the VeA protein and its associated methyltransferases in regulating secondary metabolism and fungal development. VeA forms a heterotrimeric complex with VelB and LaeA, which is crucial for coordinating development, sporulation, and pathogenicity. Recent discoveries have identified three additional methyltransferases that interact with VeA, suggesting a molecular hub function for VeA in cellular control networks. The LaeA methyltransferase is a key regulator of secondary metabolism, controlling approximately 50% of SM clusters in various fungi. It also plays a role in fungal development and has been shown to influence gene expression and post-translational modifications. LaeA's molecular function remains unclear, but it is hypothesized to regulate SM clusters epigenetically through chromatin modification. LaeA-like methyltransferases, such as LlmF, VipC, and VapB, also interact with VeA, contributing to the complexity of the regulatory network. The VeA protein interacts with various proteins, including MAPKs and light receptors, to coordinate development and secondary metabolism. These interactions suggest that VeA acts as a molecular scaffold, integrating multiple signals. The study also explores the roles of other methyltransferases, such as LlmF and VipC-VapB, in regulating gene expression and development. These proteins influence histone modifications and gene activation, highlighting their importance in fungal biology. The research underscores the significance of the velvet family proteins in fungal development and secondary metabolism. The complex interactions between VeA and its methyltransferases suggest the presence of a VeA supercomplex, which may be involved in dynamic cellular control networks. Understanding these interactions is crucial for advancing knowledge of fungal development and secondary metabolism, with potential applications in medicine, agriculture, and biotechnology. The study provides insights into the molecular mechanisms underlying fungal development and secondary metabolism, emphasizing the importance of the velvet family in these processes.Fungal secondary metabolism is a key area of research with significant biomedical and biotechnological importance. The study highlights the role of the VeA protein and its associated methyltransferases in regulating secondary metabolism and fungal development. VeA forms a heterotrimeric complex with VelB and LaeA, which is crucial for coordinating development, sporulation, and pathogenicity. Recent discoveries have identified three additional methyltransferases that interact with VeA, suggesting a molecular hub function for VeA in cellular control networks. The LaeA methyltransferase is a key regulator of secondary metabolism, controlling approximately 50% of SM clusters in various fungi. It also plays a role in fungal development and has been shown to influence gene expression and post-translational modifications. LaeA's molecular function remains unclear, but it is hypothesized to regulate SM clusters epigenetically through chromatin modification. LaeA-like methyltransferases, such as LlmF, VipC, and VapB, also interact with VeA, contributing to the complexity of the regulatory network. The VeA protein interacts with various proteins, including MAPKs and light receptors, to coordinate development and secondary metabolism. These interactions suggest that VeA acts as a molecular scaffold, integrating multiple signals. The study also explores the roles of other methyltransferases, such as LlmF and VipC-VapB, in regulating gene expression and development. These proteins influence histone modifications and gene activation, highlighting their importance in fungal biology. The research underscores the significance of the velvet family proteins in fungal development and secondary metabolism. The complex interactions between VeA and its methyltransferases suggest the presence of a VeA supercomplex, which may be involved in dynamic cellular control networks. Understanding these interactions is crucial for advancing knowledge of fungal development and secondary metabolism, with potential applications in medicine, agriculture, and biotechnology. The study provides insights into the molecular mechanisms underlying fungal development and secondary metabolism, emphasizing the importance of the velvet family in these processes.