This study, conducted using the OpenSAFELY platform, examines factors associated with COVID-19-related death in England. The platform, created for NHS England, covers 40% of all patients in England and securely stores patient data within a major vendor's primary care electronic health records system. The analysis included 17,278,392 adults, with 10,926 COVID-19-related deaths recorded. Key findings include: 1. **Demographic Factors**: COVID-19-related death was associated with being male (hazard ratio (HR) 1.59, 95% CI 1.53–1.65), older age, and greater deprivation. 2. **Medical Conditions**: Diabetes, severe asthma, and various other medical conditions were associated with increased risk. 3. **Ethnicity**: Black and South Asian individuals had higher risks compared to white individuals, even after adjusting for other factors (HR 1.48 for Black individuals, 1.45 for South Asian individuals). 4. **Other Factors**: Obesity, a history of hematological malignancy, and certain comorbidities were also associated with increased risk. The study highlights the need for targeted protection measures for vulnerable groups and emphasizes the importance of addressing social determinants of health. The findings provide a preliminary picture of the factors associated with poor outcomes from COVID-19 and can inform the development of prognostic models. The OpenSAFELY platform will continue to be updated and extended to provide regular updates on the evolving data.This study, conducted using the OpenSAFELY platform, examines factors associated with COVID-19-related death in England. The platform, created for NHS England, covers 40% of all patients in England and securely stores patient data within a major vendor's primary care electronic health records system. The analysis included 17,278,392 adults, with 10,926 COVID-19-related deaths recorded. Key findings include: 1. **Demographic Factors**: COVID-19-related death was associated with being male (hazard ratio (HR) 1.59, 95% CI 1.53–1.65), older age, and greater deprivation. 2. **Medical Conditions**: Diabetes, severe asthma, and various other medical conditions were associated with increased risk. 3. **Ethnicity**: Black and South Asian individuals had higher risks compared to white individuals, even after adjusting for other factors (HR 1.48 for Black individuals, 1.45 for South Asian individuals). 4. **Other Factors**: Obesity, a history of hematological malignancy, and certain comorbidities were also associated with increased risk. The study highlights the need for targeted protection measures for vulnerable groups and emphasizes the importance of addressing social determinants of health. The findings provide a preliminary picture of the factors associated with poor outcomes from COVID-19 and can inform the development of prognostic models. The OpenSAFELY platform will continue to be updated and extended to provide regular updates on the evolving data.