This study investigates the rheological and mechanical properties of self-compacting rubberized concrete (SCRC) using waste tire rubber aggregates (WRTA) as a substitute for coarse aggregates. The research aims to optimize the proportion of WRTA in SCRC to achieve desirable performance while minimizing environmental impact. Linear regression (LR) and extreme gradient boosting (XGBoost) were used to predict the rheological and mechanical properties of SCRC. The study tested SCRC with 0%, 5%, 10%, and 20% WRTA replacement, finding that a 10% substitution provided the best balance between workability and mechanical strength, meeting ACI standards. The 5% substitution was optimal for reducing environmental impact and managing rubber waste. The results showed a significant decrease in fresh properties with increasing WRTA content, with a 34% reduction in compressive strength and 28% decrease in splitting tensile strength at 28 days for 10% substitution. XGBoost demonstrated superior predictive performance with higher R² values compared to LR. The study also found that increasing WRTA proportion reduced workability and hardened properties, with SCRC20 showing the lowest strength. The mechanical properties tests revealed that SCRC with 10% WRTA substitution met ACI requirements. The failure patterns showed shear cracks and multiple cracks for SCRC20, while SCRC5 and SCRC10 showed pure tensile failure. The ML models showed that XGBoost was more accurate in predicting fresh and mechanical properties than LR. The study concludes that 10% WRTA substitution is optimal for SCRC, with 20% substitution suitable for urban civil works. The research highlights the potential of SCRC as an environmentally friendly alternative to conventional concrete.This study investigates the rheological and mechanical properties of self-compacting rubberized concrete (SCRC) using waste tire rubber aggregates (WRTA) as a substitute for coarse aggregates. The research aims to optimize the proportion of WRTA in SCRC to achieve desirable performance while minimizing environmental impact. Linear regression (LR) and extreme gradient boosting (XGBoost) were used to predict the rheological and mechanical properties of SCRC. The study tested SCRC with 0%, 5%, 10%, and 20% WRTA replacement, finding that a 10% substitution provided the best balance between workability and mechanical strength, meeting ACI standards. The 5% substitution was optimal for reducing environmental impact and managing rubber waste. The results showed a significant decrease in fresh properties with increasing WRTA content, with a 34% reduction in compressive strength and 28% decrease in splitting tensile strength at 28 days for 10% substitution. XGBoost demonstrated superior predictive performance with higher R² values compared to LR. The study also found that increasing WRTA proportion reduced workability and hardened properties, with SCRC20 showing the lowest strength. The mechanical properties tests revealed that SCRC with 10% WRTA substitution met ACI requirements. The failure patterns showed shear cracks and multiple cracks for SCRC20, while SCRC5 and SCRC10 showed pure tensile failure. The ML models showed that XGBoost was more accurate in predicting fresh and mechanical properties than LR. The study concludes that 10% WRTA substitution is optimal for SCRC, with 20% substitution suitable for urban civil works. The research highlights the potential of SCRC as an environmentally friendly alternative to conventional concrete.