The article "Oral Cavity and Oropharyngeal Squamous Cell Carcinoma—An Update" provides an updated overview of the epidemiology, etiology, risk factors, clinicopathologic presentation, clinical assessment, imaging, management, and prognosis of oral cavity (OC-SCC) and oropharyngeal (OP-SCC) squamous cell carcinomas. The incidence of OP-SCC has shown a significant increase, particularly in regions with high human papillomavirus (HPV) infection rates. OC-SCC remains the most common malignancy of the head and neck, excluding nonmelanoma skin cancer. Key risk factors for both types of cancer include tobacco and alcohol use, with HPV emerging as a major etiologic factor for OP-SCC. The article highlights the importance of distinguishing between OC-SCC and OP-SCC due to their distinct etiopathogenesis, treatment, and prognosis. Imaging techniques such as CT, MRI, and PET/CT are crucial for staging and assessing treatment response. The article also discusses the role of HPV testing in determining tumor origin and predicting outcomes.The article "Oral Cavity and Oropharyngeal Squamous Cell Carcinoma—An Update" provides an updated overview of the epidemiology, etiology, risk factors, clinicopathologic presentation, clinical assessment, imaging, management, and prognosis of oral cavity (OC-SCC) and oropharyngeal (OP-SCC) squamous cell carcinomas. The incidence of OP-SCC has shown a significant increase, particularly in regions with high human papillomavirus (HPV) infection rates. OC-SCC remains the most common malignancy of the head and neck, excluding nonmelanoma skin cancer. Key risk factors for both types of cancer include tobacco and alcohol use, with HPV emerging as a major etiologic factor for OP-SCC. The article highlights the importance of distinguishing between OC-SCC and OP-SCC due to their distinct etiopathogenesis, treatment, and prognosis. Imaging techniques such as CT, MRI, and PET/CT are crucial for staging and assessing treatment response. The article also discusses the role of HPV testing in determining tumor origin and predicting outcomes.