The article "Oral Cavity and Oropharyngeal Squamous Cell Carcinoma—An Update" discusses the latest evidence on oral cavity (OC) and oropharyngeal (OP) squamous cell carcinoma (SCC). It highlights the rising incidence of OP-SCC, particularly linked to human papillomavirus (HPV) infection, and contrasts OC-SCC and OP-SCC in terms of epidemiology, etiology, risk factors, diagnosis, treatment, and prognosis. The article emphasizes the importance of distinguishing between these two sites to provide appropriate patient care. It also covers the role of tobacco and alcohol as major risk factors, the increasing prevalence of HPV in OP-SCC, and the unique characteristics of HPV-positive tumors. The article discusses the clinical presentation, imaging, and staging of both OC-SCC and OP-SCC, as well as the impact of various factors such as immune status, environmental pollutants, and hereditary conditions on cancer risk. The article also addresses the importance of early detection and the need for multidisciplinary approaches in managing these cancers. The content is intended for physicians and nurses and provides educational objectives for continuing medical and nursing education. The article is part of a continuing education activity that offers credit for physicians and nurses, with specific instructions on how to earn credit. The article is available for free online and includes a quiz for participants to earn credit. The article is updated to reflect the latest research and clinical guidelines on OC-SCC and OP-SCC.The article "Oral Cavity and Oropharyngeal Squamous Cell Carcinoma—An Update" discusses the latest evidence on oral cavity (OC) and oropharyngeal (OP) squamous cell carcinoma (SCC). It highlights the rising incidence of OP-SCC, particularly linked to human papillomavirus (HPV) infection, and contrasts OC-SCC and OP-SCC in terms of epidemiology, etiology, risk factors, diagnosis, treatment, and prognosis. The article emphasizes the importance of distinguishing between these two sites to provide appropriate patient care. It also covers the role of tobacco and alcohol as major risk factors, the increasing prevalence of HPV in OP-SCC, and the unique characteristics of HPV-positive tumors. The article discusses the clinical presentation, imaging, and staging of both OC-SCC and OP-SCC, as well as the impact of various factors such as immune status, environmental pollutants, and hereditary conditions on cancer risk. The article also addresses the importance of early detection and the need for multidisciplinary approaches in managing these cancers. The content is intended for physicians and nurses and provides educational objectives for continuing medical and nursing education. The article is part of a continuing education activity that offers credit for physicians and nurses, with specific instructions on how to earn credit. The article is available for free online and includes a quiz for participants to earn credit. The article is updated to reflect the latest research and clinical guidelines on OC-SCC and OP-SCC.