The article reviews the role of osteocytes, cells embedded within the mineralized matrix of bone, in mechanosensing and Wnt signaling. Osteocytes are thought to translate mechanical loading into biochemical signals that affect bone remodeling. The Wnt/β-catenin signaling pathway is crucial for bone mass regulation and bone cell functions, with osteoblasts using it for differentiation, proliferation, and matrix synthesis, while osteocytes use it to transmit signals of mechanical loading. Recent evidence suggests that the Wnt/β-catenin pathway in osteocytes may be triggered by crosstalk with the prostaglandin pathway, leading to decreased expression of negative regulators like Sost and Dkk1. The study of osteocyte biology is becoming an intense area of research, and this review examines recent findings that are reshaping our understanding of bone and bone cell biology.The article reviews the role of osteocytes, cells embedded within the mineralized matrix of bone, in mechanosensing and Wnt signaling. Osteocytes are thought to translate mechanical loading into biochemical signals that affect bone remodeling. The Wnt/β-catenin signaling pathway is crucial for bone mass regulation and bone cell functions, with osteoblasts using it for differentiation, proliferation, and matrix synthesis, while osteocytes use it to transmit signals of mechanical loading. Recent evidence suggests that the Wnt/β-catenin pathway in osteocytes may be triggered by crosstalk with the prostaglandin pathway, leading to decreased expression of negative regulators like Sost and Dkk1. The study of osteocyte biology is becoming an intense area of research, and this review examines recent findings that are reshaping our understanding of bone and bone cell biology.