This report, prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA), provides a comprehensive overview of osteoporosis in the 27 countries of the European Union (EU27). It covers the epidemiology, burden, and treatment of osteoporosis, highlighting the significant social and economic impact of the disease. Key findings include: - **Prevalence**: An estimated 22 million women and 5.5 million men in the EU27 have osteoporosis. - **Fracture Incidence**: In 2010, 3.5 million new fragility fractures were sustained, including 610,000 hip fractures, 520,000 vertebral fractures, 560,000 forearm fractures, and 1,800,000 other fractures. - **Economic Burden**: The economic burden of incident and prior fragility fractures was estimated at €37 billion, with incident fractures accounting for 66% of this cost, long-term fracture care for 29%, and pharmacological prevention for 5%. - **Quality-Adjusted Life Years (QALYs)**: Fractures resulted in 1,180,000 QALYs lost in 2010, with projections indicating a 25% increase by 2025. - **Treatment Gap**: Despite the high social and economic cost, a substantial treatment gap exists, and the number of patients on treatment is declining. The report emphasizes the need for healthcare policy changes to address the increasing burden of osteoporosis, particularly in aging populations. It also highlights the importance of improving adherence to treatment and the development of new interventions to reduce the risk of fractures.This report, prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA), provides a comprehensive overview of osteoporosis in the 27 countries of the European Union (EU27). It covers the epidemiology, burden, and treatment of osteoporosis, highlighting the significant social and economic impact of the disease. Key findings include: - **Prevalence**: An estimated 22 million women and 5.5 million men in the EU27 have osteoporosis. - **Fracture Incidence**: In 2010, 3.5 million new fragility fractures were sustained, including 610,000 hip fractures, 520,000 vertebral fractures, 560,000 forearm fractures, and 1,800,000 other fractures. - **Economic Burden**: The economic burden of incident and prior fragility fractures was estimated at €37 billion, with incident fractures accounting for 66% of this cost, long-term fracture care for 29%, and pharmacological prevention for 5%. - **Quality-Adjusted Life Years (QALYs)**: Fractures resulted in 1,180,000 QALYs lost in 2010, with projections indicating a 25% increase by 2025. - **Treatment Gap**: Despite the high social and economic cost, a substantial treatment gap exists, and the number of patients on treatment is declining. The report emphasizes the need for healthcare policy changes to address the increasing burden of osteoporosis, particularly in aging populations. It also highlights the importance of improving adherence to treatment and the development of new interventions to reduce the risk of fractures.