The article "Osteoporosis Treatment: Current Drugs and Future Developments" by Ya-jing Chen et al. provides an overview of the current state and future prospects of osteoporosis treatment. Osteoporosis is a systemic metabolic disease characterized by decreased bone density, microstructural damage, and increased fragility, leading to an increased risk of fractures. The article discusses the pathogenesis of osteoporosis, including the roles of calcium, parathyroid hormone (PTH), bone remodeling, and immune system regulation. It also reviews the current clinical applications of anti-osteoporosis drugs, such as fluoride, parathyroid hormone analogues, statins, and androgens, and their mechanisms of action. Additionally, the article explores new drugs like denosumab, romosozumab, biosozumab, and odanacatib, highlighting their efficacy and potential side effects. The section on traditional Chinese medicine (TCM) emphasizes the use of herbal products and acupuncture for treating osteoporosis, detailing the active ingredients and mechanisms of action of various TCM compounds. The article concludes by discussing the future directions in osteoporosis treatment, including the development of new drugs and the integration of TCM with modern pharmacological approaches.The article "Osteoporosis Treatment: Current Drugs and Future Developments" by Ya-jing Chen et al. provides an overview of the current state and future prospects of osteoporosis treatment. Osteoporosis is a systemic metabolic disease characterized by decreased bone density, microstructural damage, and increased fragility, leading to an increased risk of fractures. The article discusses the pathogenesis of osteoporosis, including the roles of calcium, parathyroid hormone (PTH), bone remodeling, and immune system regulation. It also reviews the current clinical applications of anti-osteoporosis drugs, such as fluoride, parathyroid hormone analogues, statins, and androgens, and their mechanisms of action. Additionally, the article explores new drugs like denosumab, romosozumab, biosozumab, and odanacatib, highlighting their efficacy and potential side effects. The section on traditional Chinese medicine (TCM) emphasizes the use of herbal products and acupuncture for treating osteoporosis, detailing the active ingredients and mechanisms of action of various TCM compounds. The article concludes by discussing the future directions in osteoporosis treatment, including the development of new drugs and the integration of TCM with modern pharmacological approaches.