| Ghassan B. Hamra, Neela Guha, Aaron Cohen, Francine Laden, Ole Raaschou-Nielsen, Jonathan M. Samet, Paolo Vineis, Francesco Forastiere, Paulo Saldiva, Takashi Yorifuji, and Dana Loomis
This document provides supplemental materials for the study "Outdoor Particulate Matter Exposure and Lung Cancer: A Systematic Review and Meta-Analysis." Figure S1 shows funnel plots for studies examining the association between lung cancer incidence and mortality with PM2.5 and PM10. The center lines of the funnel plots represent a fixed effect meta-estimate, not a random effect, and thus do not match the estimates in Table 2 of the main manuscript. Additionally, the study by Jerrett et al. (2013) is excluded from the PM2.5 funnel plot. The funnel plots were generated using the STATA package metafunnel. Table S1 presents influence analyses assessing the impact of a 10 µg/m³ increase in PM2.5 and PM10 exposure on lung cancer incidence and mortality. These analyses help evaluate the robustness of the study findings by identifying any potential outliers or influential studies that may affect the overall results. The supplemental materials aim to provide additional insights into the study's findings and enhance the transparency and reliability of the research. The results of the systematic review and meta-analysis suggest a significant association between exposure to outdoor particulate matter and the risk of lung cancer, with PM2.5 showing a stronger association than PM10. The study highlights the importance of reducing exposure to fine particulate matter to lower the risk of lung cancer. The supplemental materials support the main findings and provide a more comprehensive understanding of the relationship between outdoor air pollution and lung cancer.This document provides supplemental materials for the study "Outdoor Particulate Matter Exposure and Lung Cancer: A Systematic Review and Meta-Analysis." Figure S1 shows funnel plots for studies examining the association between lung cancer incidence and mortality with PM2.5 and PM10. The center lines of the funnel plots represent a fixed effect meta-estimate, not a random effect, and thus do not match the estimates in Table 2 of the main manuscript. Additionally, the study by Jerrett et al. (2013) is excluded from the PM2.5 funnel plot. The funnel plots were generated using the STATA package metafunnel. Table S1 presents influence analyses assessing the impact of a 10 µg/m³ increase in PM2.5 and PM10 exposure on lung cancer incidence and mortality. These analyses help evaluate the robustness of the study findings by identifying any potential outliers or influential studies that may affect the overall results. The supplemental materials aim to provide additional insights into the study's findings and enhance the transparency and reliability of the research. The results of the systematic review and meta-analysis suggest a significant association between exposure to outdoor particulate matter and the risk of lung cancer, with PM2.5 showing a stronger association than PM10. The study highlights the importance of reducing exposure to fine particulate matter to lower the risk of lung cancer. The supplemental materials support the main findings and provide a more comprehensive understanding of the relationship between outdoor air pollution and lung cancer.