This review focuses on the energy metabolism of oocytes in the context of ovarian aging and its impact on oocyte quality. As women age, the quantity and quality of their follicles or oocytes decline, leading to decreased ovarian reserve function (DOR) and reduced oocyte quality. Age-related changes in oocyte energy metabolism, particularly in the Tricarboxylic Acid (TCA) cycle, Oxidative Phosphorylation (OXPHOS), Lipid Metabolism, Glutamine Metabolism, and Adenosine Remedial Pathway, are key factors in this process. These changes affect ATP production and related products and proteins, ultimately impacting oocyte quality and fertility. The TCA cycle, which is crucial for energy production, shows decreased activity with age, leading to reduced NAD+ levels and impaired mitochondrial function. OXPHOS, another critical pathway, also declines, affecting ATP synthesis and contributing to oxidative stress. Lipid metabolism changes, with reduced fatty acid oxidation capacity and increased lipid accumulation, further impact oocyte quality. Glutamine, an essential carbon source, accumulates in oocytes with age, potentially affecting cellular metabolism and aging through various pathways. Epigenetic changes, such as DNA methylation and histone modifications, also play a role in the decline of oocyte quality. Key proteins like Sirtuins (SIRTs) and Forkhead Box O3a (FoxO3a) regulate energy metabolism in aging oocytes, with their expression and function altering with age. The review highlights the need for further research to identify biomarkers and therapeutic strategies to enhance oocyte quality and fertility in older women.This review focuses on the energy metabolism of oocytes in the context of ovarian aging and its impact on oocyte quality. As women age, the quantity and quality of their follicles or oocytes decline, leading to decreased ovarian reserve function (DOR) and reduced oocyte quality. Age-related changes in oocyte energy metabolism, particularly in the Tricarboxylic Acid (TCA) cycle, Oxidative Phosphorylation (OXPHOS), Lipid Metabolism, Glutamine Metabolism, and Adenosine Remedial Pathway, are key factors in this process. These changes affect ATP production and related products and proteins, ultimately impacting oocyte quality and fertility. The TCA cycle, which is crucial for energy production, shows decreased activity with age, leading to reduced NAD+ levels and impaired mitochondrial function. OXPHOS, another critical pathway, also declines, affecting ATP synthesis and contributing to oxidative stress. Lipid metabolism changes, with reduced fatty acid oxidation capacity and increased lipid accumulation, further impact oocyte quality. Glutamine, an essential carbon source, accumulates in oocytes with age, potentially affecting cellular metabolism and aging through various pathways. Epigenetic changes, such as DNA methylation and histone modifications, also play a role in the decline of oocyte quality. Key proteins like Sirtuins (SIRTs) and Forkhead Box O3a (FoxO3a) regulate energy metabolism in aging oocytes, with their expression and function altering with age. The review highlights the need for further research to identify biomarkers and therapeutic strategies to enhance oocyte quality and fertility in older women.