This article reviews recent advances in formulation and delivery strategies for biopharmaceutical drugs, such as monoclonal antibodies and recombinant proteins, which face challenges due to their large size and susceptibility to degradation. The review highlights various strategies, including microsphere-based controlled-release technologies, protein modification with polymers, and genetic manipulation, as well as alternative delivery routes like transdermal, oral, and pulmonary. It discusses the potential of targeted and intracellular delivery, and the impact of biopharmaceuticals on the pharmaceutical industry. The article also covers advanced formulations, such as microparticles and nanoparticles, which have been used for sustained drug release and targeted delivery. Depot injections, injectable implants, and modified peptides and proteins are also discussed, along with their advantages and challenges. The review emphasizes the importance of improving drug stability, reducing immunogenicity, and enhancing bioavailability. It also explores alternative delivery routes, including oral, transdermal, and needle-free injectors, and highlights the challenges and opportunities in each. Finally, the article discusses targeted and intracellular delivery, focusing on the blood-brain barrier and the development of therapies for neurodegenerative diseases. The review concludes that while biopharmaceuticals present significant challenges, recent advances in formulation and delivery strategies have enabled their successful development and application.This article reviews recent advances in formulation and delivery strategies for biopharmaceutical drugs, such as monoclonal antibodies and recombinant proteins, which face challenges due to their large size and susceptibility to degradation. The review highlights various strategies, including microsphere-based controlled-release technologies, protein modification with polymers, and genetic manipulation, as well as alternative delivery routes like transdermal, oral, and pulmonary. It discusses the potential of targeted and intracellular delivery, and the impact of biopharmaceuticals on the pharmaceutical industry. The article also covers advanced formulations, such as microparticles and nanoparticles, which have been used for sustained drug release and targeted delivery. Depot injections, injectable implants, and modified peptides and proteins are also discussed, along with their advantages and challenges. The review emphasizes the importance of improving drug stability, reducing immunogenicity, and enhancing bioavailability. It also explores alternative delivery routes, including oral, transdermal, and needle-free injectors, and highlights the challenges and opportunities in each. Finally, the article discusses targeted and intracellular delivery, focusing on the blood-brain barrier and the development of therapies for neurodegenerative diseases. The review concludes that while biopharmaceuticals present significant challenges, recent advances in formulation and delivery strategies have enabled their successful development and application.