This review explores the role of sleep in emotional brain processing, highlighting the interaction between sleep and emotional regulation. It discusses the neurobiological mechanisms underlying sleep-dependent emotional memory encoding and consolidation, and the impact of sleep loss on emotional reactivity and mood disorders. The authors propose a model of sleep-dependent emotional information processing, suggesting that sleep modulates affective neural systems and reprocesses recent emotional experiences, particularly during REM sleep. The review also examines the relationship between sleep abnormalities and mood disorders such as major depression and post-traumatic stress disorder (PTSD), emphasizing the potential clinical implications of these findings.This review explores the role of sleep in emotional brain processing, highlighting the interaction between sleep and emotional regulation. It discusses the neurobiological mechanisms underlying sleep-dependent emotional memory encoding and consolidation, and the impact of sleep loss on emotional reactivity and mood disorders. The authors propose a model of sleep-dependent emotional information processing, suggesting that sleep modulates affective neural systems and reprocesses recent emotional experiences, particularly during REM sleep. The review also examines the relationship between sleep abnormalities and mood disorders such as major depression and post-traumatic stress disorder (PTSD), emphasizing the potential clinical implications of these findings.