The article provides an overview of Problem-based Learning (PBL), a learner-centered instructional approach that has been successfully used for over 30 years across various disciplines. PBL empowers learners to conduct research, integrate theory and practice, and apply knowledge to solve defined problems. The author discusses the history of PBL, its origins in medical education, and its expansion into other fields. Despite some challenges and ongoing debates about its effectiveness, PBL has gained widespread adoption in educational settings from elementary schools to professional programs. The article highlights the essential characteristics of PBL, including the role of the tutor, learner responsibility, ill-structured problems, interdisciplinary integration, collaboration, and reflection. It also compares PBL with case-based and project-based learning, emphasizing the unique aspects of PBL. Finally, the article addresses the challenges and future prospects of PBL, noting the need for further research and the importance of adapting PBL to meet the demands of the 21st century.The article provides an overview of Problem-based Learning (PBL), a learner-centered instructional approach that has been successfully used for over 30 years across various disciplines. PBL empowers learners to conduct research, integrate theory and practice, and apply knowledge to solve defined problems. The author discusses the history of PBL, its origins in medical education, and its expansion into other fields. Despite some challenges and ongoing debates about its effectiveness, PBL has gained widespread adoption in educational settings from elementary schools to professional programs. The article highlights the essential characteristics of PBL, including the role of the tutor, learner responsibility, ill-structured problems, interdisciplinary integration, collaboration, and reflection. It also compares PBL with case-based and project-based learning, emphasizing the unique aspects of PBL. Finally, the article addresses the challenges and future prospects of PBL, noting the need for further research and the importance of adapting PBL to meet the demands of the 21st century.