The article provides a comprehensive overview of the pathogenicity and virulence of *Proteus mirabilis* (P. mirabilis), a Gram-negative bacterium known for its role in various human infections, particularly urinary tract infections (UTIs). The bacterium is characterized by its swarming motility, urease production, and ability to form biofilms, which facilitate its colonization and persistence in host tissues. P. mirabilis is particularly associated with catheter-associated UTIs (CAUTIs) and can lead to severe complications such as urolithiasis and bacteremia, especially in immunocompromised patients. The bacterium's virulence factors, including fimbriae, hemolysin, proteases, and urease, are detailed, highlighting their roles in adhesion, tissue damage, and immune evasion. The article also discusses the bacterium's metal acquisition systems, focusing on its ability to import nickel for urease activity and zinc for survival and pathogenicity. These systems are crucial for P. mirabilis' survival and virulence, and understanding them could inform therapeutic strategies to combat infections. The review emphasizes the need for further research to elucidate the specific roles of metallophores in shaping P. mirabilis' virulence factors and to develop targeted interventions.The article provides a comprehensive overview of the pathogenicity and virulence of *Proteus mirabilis* (P. mirabilis), a Gram-negative bacterium known for its role in various human infections, particularly urinary tract infections (UTIs). The bacterium is characterized by its swarming motility, urease production, and ability to form biofilms, which facilitate its colonization and persistence in host tissues. P. mirabilis is particularly associated with catheter-associated UTIs (CAUTIs) and can lead to severe complications such as urolithiasis and bacteremia, especially in immunocompromised patients. The bacterium's virulence factors, including fimbriae, hemolysin, proteases, and urease, are detailed, highlighting their roles in adhesion, tissue damage, and immune evasion. The article also discusses the bacterium's metal acquisition systems, focusing on its ability to import nickel for urease activity and zinc for survival and pathogenicity. These systems are crucial for P. mirabilis' survival and virulence, and understanding them could inform therapeutic strategies to combat infections. The review emphasizes the need for further research to elucidate the specific roles of metallophores in shaping P. mirabilis' virulence factors and to develop targeted interventions.