The article provides an overview of oxidative stress (OS) and inflammation in the context of diabetes, highlighting their roles in the development and progression of type 2 diabetes mellitus (T2D) and its complications. Chronic inflammation, driven by poor nutrition, unhealthy lifestyles, and toxin exposure, increases the risk of chronic diseases and T2D complications. OS and ROS contribute to insulin resistance and β-cell dysfunction, while anti-inflammatory agents and antioxidants can help prevent these conditions. The review discusses the pathophysiology of T2D, focusing on low-grade chronic inflammation and OS, and their impact on insulin resistance. It also explores the role of inflammatory cytokines, stress kinases, and ROS in disrupting insulin signaling pathways, leading to impaired glucose metabolism and organ dysfunction. Lifestyle interventions, including a balanced diet, regular exercise, and an antioxidant-rich diet, are emphasized as effective strategies for reducing chronic inflammation and OS, thereby preventing and controlling T2D and its complications. Additionally, various antioxidants and anti-inflammatory agents, as well as anti-diabetic medications like pioglitazone, metformin, and GLP-1 agonists, are shown to have potential in reducing OS and inflammation. Further research, including randomized controlled trials, is needed to evaluate the efficacy of these interventions.The article provides an overview of oxidative stress (OS) and inflammation in the context of diabetes, highlighting their roles in the development and progression of type 2 diabetes mellitus (T2D) and its complications. Chronic inflammation, driven by poor nutrition, unhealthy lifestyles, and toxin exposure, increases the risk of chronic diseases and T2D complications. OS and ROS contribute to insulin resistance and β-cell dysfunction, while anti-inflammatory agents and antioxidants can help prevent these conditions. The review discusses the pathophysiology of T2D, focusing on low-grade chronic inflammation and OS, and their impact on insulin resistance. It also explores the role of inflammatory cytokines, stress kinases, and ROS in disrupting insulin signaling pathways, leading to impaired glucose metabolism and organ dysfunction. Lifestyle interventions, including a balanced diet, regular exercise, and an antioxidant-rich diet, are emphasized as effective strategies for reducing chronic inflammation and OS, thereby preventing and controlling T2D and its complications. Additionally, various antioxidants and anti-inflammatory agents, as well as anti-diabetic medications like pioglitazone, metformin, and GLP-1 agonists, are shown to have potential in reducing OS and inflammation. Further research, including randomized controlled trials, is needed to evaluate the efficacy of these interventions.