This paper demonstrates the use of graphene films grown by chemical vapor deposition (CVD) to protect the surfaces of Cu and Cu/Ni alloy substrates from air oxidation and hydrogen peroxide. The graphene coating, which is transparent, conductive, and chemically inert, effectively prevents the diffusion of oxidizing agents and maintains the metal surfaces in pristine condition even after prolonged exposure to high temperatures and oxidizing solutions. SEM, Raman spectroscopy, and XPS studies confirm the excellent oxidation resistance of the graphene-coated samples, with minimal changes observed in the metal surfaces compared to uncoated samples. The graphene's impermeability and chemical stability make it an ideal protective layer, offering significant advantages over conventional protective coatings in terms of chemical and thermal stability, minimal physical property changes, and cost-effectiveness. The research highlights the potential of graphene as a versatile and effective passivation layer for a wide range of metals, including Cu, Ni, Fe, Ta, Pt, Ir, and Ru, and their alloys.This paper demonstrates the use of graphene films grown by chemical vapor deposition (CVD) to protect the surfaces of Cu and Cu/Ni alloy substrates from air oxidation and hydrogen peroxide. The graphene coating, which is transparent, conductive, and chemically inert, effectively prevents the diffusion of oxidizing agents and maintains the metal surfaces in pristine condition even after prolonged exposure to high temperatures and oxidizing solutions. SEM, Raman spectroscopy, and XPS studies confirm the excellent oxidation resistance of the graphene-coated samples, with minimal changes observed in the metal surfaces compared to uncoated samples. The graphene's impermeability and chemical stability make it an ideal protective layer, offering significant advantages over conventional protective coatings in terms of chemical and thermal stability, minimal physical property changes, and cost-effectiveness. The research highlights the potential of graphene as a versatile and effective passivation layer for a wide range of metals, including Cu, Ni, Fe, Ta, Pt, Ir, and Ru, and their alloys.