Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra. Oxidative stress has been identified as a key factor in the development and progression of PD. The article discusses the sources of oxidative stress in PD, including mitochondrial dysfunction, dopamine metabolism, and neuroinflammation. It explores the potential of antioxidant therapy as a treatment approach, highlighting the challenges of delivering antioxidants to the brain and the need for biomarkers to track oxidative stress in PD patients. Despite the promise of antioxidant therapy, further research is needed to determine its efficacy and safety in PD treatment. The article also reviews the pathophysiology of PD, focusing on the role of mitochondria, neuroinflammation, and oxidative stress. It examines the interplay between dopamine metabolism and oxidative stress, and discusses various treatments targeting oxidative stress, such as vitamins E and C, creatine, coenzyme Q10 (CoQ10), MitoQ, and phytochemicals like quercetin. The article concludes by emphasizing the complexity of PD pathology and the need for further research to develop effective treatments.Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra. Oxidative stress has been identified as a key factor in the development and progression of PD. The article discusses the sources of oxidative stress in PD, including mitochondrial dysfunction, dopamine metabolism, and neuroinflammation. It explores the potential of antioxidant therapy as a treatment approach, highlighting the challenges of delivering antioxidants to the brain and the need for biomarkers to track oxidative stress in PD patients. Despite the promise of antioxidant therapy, further research is needed to determine its efficacy and safety in PD treatment. The article also reviews the pathophysiology of PD, focusing on the role of mitochondria, neuroinflammation, and oxidative stress. It examines the interplay between dopamine metabolism and oxidative stress, and discusses various treatments targeting oxidative stress, such as vitamins E and C, creatine, coenzyme Q10 (CoQ10), MitoQ, and phytochemicals like quercetin. The article concludes by emphasizing the complexity of PD pathology and the need for further research to develop effective treatments.