This review article explores the link between oxidative stress and Alzheimer's disease (AD), a neurodegenerative disorder characterized by the accumulation of amyloid-beta peptide (Aβ) and metal ions such as copper, iron, and zinc. Oxidative stress, defined as an imbalance between ROS production and antioxidant defenses, is a key factor in AD pathogenesis. The article highlights how redox-active metal ions can catalyze the production of ROS, particularly hydroxyl radicals, which damage both the Aβ peptide and surrounding molecules. The review discusses the coordination of Aβ with metal ions, the production of ROS by Aβ-metals, and the oxidative damages undergone by the Aβ peptide. It also examines the implications of metal ions in AD, their interaction with Aβ, and the molecular mechanisms of Aβ oxidation. The article emphasizes the importance of understanding these processes for developing therapeutic strategies targeting oxidative stress in AD.This review article explores the link between oxidative stress and Alzheimer's disease (AD), a neurodegenerative disorder characterized by the accumulation of amyloid-beta peptide (Aβ) and metal ions such as copper, iron, and zinc. Oxidative stress, defined as an imbalance between ROS production and antioxidant defenses, is a key factor in AD pathogenesis. The article highlights how redox-active metal ions can catalyze the production of ROS, particularly hydroxyl radicals, which damage both the Aβ peptide and surrounding molecules. The review discusses the coordination of Aβ with metal ions, the production of ROS by Aβ-metals, and the oxidative damages undergone by the Aβ peptide. It also examines the implications of metal ions in AD, their interaction with Aβ, and the molecular mechanisms of Aβ oxidation. The article emphasizes the importance of understanding these processes for developing therapeutic strategies targeting oxidative stress in AD.