The article discusses the crucial role of oxidative stress in various liver diseases. Oxidative stress, an imbalance between oxidant and antioxidant agents, is primarily produced in hepatocytes through cytochrome P450 enzymes and mitochondria. This stress affects cellular structures such as proteins, lipids, and DNA, leading to structural and functional abnormalities in the liver. The authors highlight the importance of oxidative stress in the pathogenesis of liver disorders, including alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), hepatic encephalopathy, liver fibroproliferative diseases, and hepatitis C virus (HCV) infection. They also explore the role of melatonin, a unique antioxidant, in mitigating oxidative stress and its potential therapeutic applications. The article emphasizes the need for further research to understand and manage oxidative stress in liver diseases, as it plays a significant role in the progression and severity of these conditions.The article discusses the crucial role of oxidative stress in various liver diseases. Oxidative stress, an imbalance between oxidant and antioxidant agents, is primarily produced in hepatocytes through cytochrome P450 enzymes and mitochondria. This stress affects cellular structures such as proteins, lipids, and DNA, leading to structural and functional abnormalities in the liver. The authors highlight the importance of oxidative stress in the pathogenesis of liver disorders, including alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), hepatic encephalopathy, liver fibroproliferative diseases, and hepatitis C virus (HCV) infection. They also explore the role of melatonin, a unique antioxidant, in mitigating oxidative stress and its potential therapeutic applications. The article emphasizes the need for further research to understand and manage oxidative stress in liver diseases, as it plays a significant role in the progression and severity of these conditions.