The PI3K/AKT signaling pathway plays a crucial role in regulating autophagy and apoptosis in oral squamous cell carcinoma (OSCC). This review discusses the regulation of the PI3K/AKT/mTOR pathway and its role in controlling autophagy and apoptosis during the progression and metastasis of OSCC. The pathway is involved in various cellular processes, including cell survival, proliferation, and metabolism. The review also highlights the upstream activators and downstream effectors of the PI3K/AKT/mTOR signaling pathway as potential therapeutic targets for oral cancer treatment. The PI3K/AKT pathway is commonly modulated in oral cancer, and its dysregulation is associated with increased cell proliferation, resistance to chemotherapy, and poor prognosis. The pathway is involved in the regulation of autophagy, which is a cellular process that degrades and recycles cellular components. Autophagy is essential for maintaining cellular homeostasis and can be influenced by various factors, including reactive oxygen species (ROS). The review also discusses the role of epigenetic modifications in regulating the PI3K/AKT pathway and autophagy. The PI3K/AKT pathway is a potential therapeutic target for oral cancer, and various inhibitors of the pathway are being investigated for their efficacy in treating OSCC. The review highlights the importance of targeting the PI3K/AKT pathway in the treatment of oral cancer and the need for further research to develop more effective therapies.The PI3K/AKT signaling pathway plays a crucial role in regulating autophagy and apoptosis in oral squamous cell carcinoma (OSCC). This review discusses the regulation of the PI3K/AKT/mTOR pathway and its role in controlling autophagy and apoptosis during the progression and metastasis of OSCC. The pathway is involved in various cellular processes, including cell survival, proliferation, and metabolism. The review also highlights the upstream activators and downstream effectors of the PI3K/AKT/mTOR signaling pathway as potential therapeutic targets for oral cancer treatment. The PI3K/AKT pathway is commonly modulated in oral cancer, and its dysregulation is associated with increased cell proliferation, resistance to chemotherapy, and poor prognosis. The pathway is involved in the regulation of autophagy, which is a cellular process that degrades and recycles cellular components. Autophagy is essential for maintaining cellular homeostasis and can be influenced by various factors, including reactive oxygen species (ROS). The review also discusses the role of epigenetic modifications in regulating the PI3K/AKT pathway and autophagy. The PI3K/AKT pathway is a potential therapeutic target for oral cancer, and various inhibitors of the pathway are being investigated for their efficacy in treating OSCC. The review highlights the importance of targeting the PI3K/AKT pathway in the treatment of oral cancer and the need for further research to develop more effective therapies.