The chapter outlines the PISA 2018 Assessment and Analytical Framework, focusing on the global competence, questionnaire, and well-being frameworks. It begins with an introduction to the importance of assessing global competence, followed by detailed sections on the cognitive assessment scenarios and possible topics for the cognitive test. The questionnaire framework is then discussed, covering policy issues and the core components of the assessment. The well-being framework is introduced, emphasizing its multi-dimensional nature and addressing measurement challenges, with suggested quality of life indicators. The chapter also includes background questionnaires and expert groups involved in the development of the framework.The chapter outlines the PISA 2018 Assessment and Analytical Framework, focusing on the global competence, questionnaire, and well-being frameworks. It begins with an introduction to the importance of assessing global competence, followed by detailed sections on the cognitive assessment scenarios and possible topics for the cognitive test. The questionnaire framework is then discussed, covering policy issues and the core components of the assessment. The well-being framework is introduced, emphasizing its multi-dimensional nature and addressing measurement challenges, with suggested quality of life indicators. The chapter also includes background questionnaires and expert groups involved in the development of the framework.