PROSITE is a comprehensive database that compiles sites and patterns found in protein sequences, serving as a crucial tool for sequence analysis and protein function determination. Developed since 1988, PROSITE includes two main components: PROSITE.DAT, a computer-readable file containing pattern information and statistics, and PROSITE.DOC, a textual documentation file. The database follows four key concepts: completeness, high specificity, documentation, and periodic reviewing. As of Release 8.10 (March 1992), PROSITE contains 530 documentation entries describing 605 different patterns. It is distributed on magnetic tape and CD-ROM by the EMBL Data Library, with no restrictions on use or redistribution. The database is regularly updated, with four releases per year, and can be accessed via the EMBL File Server and FTP from various file servers.PROSITE is a comprehensive database that compiles sites and patterns found in protein sequences, serving as a crucial tool for sequence analysis and protein function determination. Developed since 1988, PROSITE includes two main components: PROSITE.DAT, a computer-readable file containing pattern information and statistics, and PROSITE.DOC, a textual documentation file. The database follows four key concepts: completeness, high specificity, documentation, and periodic reviewing. As of Release 8.10 (March 1992), PROSITE contains 530 documentation entries describing 605 different patterns. It is distributed on magnetic tape and CD-ROM by the EMBL Data Library, with no restrictions on use or redistribution. The database is regularly updated, with four releases per year, and can be accessed via the EMBL File Server and FTP from various file servers.