Public-Private Partnerships (PPPs) have emerged as a crucial mechanism for fostering innovation in the health sector globally. This review examines diverse PPP models worldwide, highlighting their significance and impact. PPPs in healthcare innovation involve collaboration between governmental bodies, private enterprises, and sometimes non-profit organizations to address challenges such as limited resources, expertise, and infrastructure. Effective governance structures, clear objectives, and mutual accountability are key to the success of PPPs. Notable examples include the United Kingdom's NHS Innovation Accelerator, which partners with industry leaders to fast-track the adoption of innovative healthcare technologies, and the Medicines for Malaria Venture (MMV), which collaborates with pharmaceutical companies, governments, and research institutions to develop affordable antimalarial drugs. In low-resource settings like sub-Saharan Africa, PPPs have played a pivotal role in improving access to essential healthcare services. However, challenges such as complex regulatory frameworks, funding uncertainties, and divergent interests among stakeholders persist. Lessons from successful PPPs emphasize the importance of transparent communication, stakeholder engagement, and sustained political commitment. In conclusion, PPPs in the health sector represent a dynamic avenue for catalyzing innovation and driving transformative change. By drawing insights from diverse experiences worldwide, policymakers and practitioners can refine existing frameworks and foster sustainable partnerships to tackle evolving health challenges effectively.Public-Private Partnerships (PPPs) have emerged as a crucial mechanism for fostering innovation in the health sector globally. This review examines diverse PPP models worldwide, highlighting their significance and impact. PPPs in healthcare innovation involve collaboration between governmental bodies, private enterprises, and sometimes non-profit organizations to address challenges such as limited resources, expertise, and infrastructure. Effective governance structures, clear objectives, and mutual accountability are key to the success of PPPs. Notable examples include the United Kingdom's NHS Innovation Accelerator, which partners with industry leaders to fast-track the adoption of innovative healthcare technologies, and the Medicines for Malaria Venture (MMV), which collaborates with pharmaceutical companies, governments, and research institutions to develop affordable antimalarial drugs. In low-resource settings like sub-Saharan Africa, PPPs have played a pivotal role in improving access to essential healthcare services. However, challenges such as complex regulatory frameworks, funding uncertainties, and divergent interests among stakeholders persist. Lessons from successful PPPs emphasize the importance of transparent communication, stakeholder engagement, and sustained political commitment. In conclusion, PPPs in the health sector represent a dynamic avenue for catalyzing innovation and driving transformative change. By drawing insights from diverse experiences worldwide, policymakers and practitioners can refine existing frameworks and foster sustainable partnerships to tackle evolving health challenges effectively.