The article explores the interactions between pain and emotion in the cingulate gyrus, a brain region involved in both sensory-discriminative and affective-motivational aspects of pain processing. The cingulate gyrus is divided into four subregions—anterior cingulate cortex (ACC), midcingulate cortex (MCC), posterior cingulate cortex (PCC), and retrosplenial cortex (RSC)—each with distinct functions and connections. The study assesses whether pain and negative affect are co-localized in these subregions and finds that activation patterns do not simply overlap. The ACC is involved in autonomic control and emotional memory storage, while the MCC is involved in response selection and premotor planning. The PCC is involved in visuospatial orientation, and the RSC is poorly understood but likely plays a role in memory access. The article also discusses the sources of nociceptive inputs to the cingulate cortex, which primarily come from the thalamus, and the role of different subregions in nociception and emotion processing. Finally, it explores the implications of these findings for understanding pain regulation, hypnotic analgesia, and placebo effects.The article explores the interactions between pain and emotion in the cingulate gyrus, a brain region involved in both sensory-discriminative and affective-motivational aspects of pain processing. The cingulate gyrus is divided into four subregions—anterior cingulate cortex (ACC), midcingulate cortex (MCC), posterior cingulate cortex (PCC), and retrosplenial cortex (RSC)—each with distinct functions and connections. The study assesses whether pain and negative affect are co-localized in these subregions and finds that activation patterns do not simply overlap. The ACC is involved in autonomic control and emotional memory storage, while the MCC is involved in response selection and premotor planning. The PCC is involved in visuospatial orientation, and the RSC is poorly understood but likely plays a role in memory access. The article also discusses the sources of nociceptive inputs to the cingulate cortex, which primarily come from the thalamus, and the role of different subregions in nociception and emotion processing. Finally, it explores the implications of these findings for understanding pain regulation, hypnotic analgesia, and placebo effects.