This paper presents a series of ten time-slices covering the palaeogeography of the Mediterranean and Paratethys Seas from the late Eocene to the Miocene. The slices highlight significant changes in seaway connections and land bridge formations, which influenced continental migrations and faunal exchanges. The Tethys Ocean disappeared in the late Eocene due to the northward drift of India and the counterclockwise rotation of Africa, leading to the formation of the Mediterranean Sea and the Paratethys Basin. The Turgai Strait, which connected the Tethys with the Polar Sea, was closed, facilitating mammal migrations between Asia and Europe. The Paratethys Basin experienced significant changes, transitioning from an open ocean in the Eocene to an enclosed basin in the early Oligocene, with reduced salinity and endemic faunas. By the middle Oligocene, the basin reopened, reaching maximum connection with the Indian Ocean during the late Oligocene and early Miocene. Intermittent seaways and regional closures characterized the late Burdigalian and middle Miocene, leading to the final disconnection of the Paratethys in the mid-Serravallian. The Mediterranean remained a connecting sea between the Indo-Pacific and Atlantic Oceans until the late Burdigalian. The collision of the Arabian and Anatolian plates in the late Burdigalian opened a Eurasian-African land bridge for mammal migrations. The paper also discusses the stratigraphic correlation between the Mediterranean standard scale and the regional stage systems of the Central and Eastern Paratethys, providing insights into the palaeogeographic and palaeoecological developments.This paper presents a series of ten time-slices covering the palaeogeography of the Mediterranean and Paratethys Seas from the late Eocene to the Miocene. The slices highlight significant changes in seaway connections and land bridge formations, which influenced continental migrations and faunal exchanges. The Tethys Ocean disappeared in the late Eocene due to the northward drift of India and the counterclockwise rotation of Africa, leading to the formation of the Mediterranean Sea and the Paratethys Basin. The Turgai Strait, which connected the Tethys with the Polar Sea, was closed, facilitating mammal migrations between Asia and Europe. The Paratethys Basin experienced significant changes, transitioning from an open ocean in the Eocene to an enclosed basin in the early Oligocene, with reduced salinity and endemic faunas. By the middle Oligocene, the basin reopened, reaching maximum connection with the Indian Ocean during the late Oligocene and early Miocene. Intermittent seaways and regional closures characterized the late Burdigalian and middle Miocene, leading to the final disconnection of the Paratethys in the mid-Serravallian. The Mediterranean remained a connecting sea between the Indo-Pacific and Atlantic Oceans until the late Burdigalian. The collision of the Arabian and Anatolian plates in the late Burdigalian opened a Eurasian-African land bridge for mammal migrations. The paper also discusses the stratigraphic correlation between the Mediterranean standard scale and the regional stage systems of the Central and Eastern Paratethys, providing insights into the palaeogeographic and palaeoecological developments.