The article argues that Parkinson's disease (PD) has a significant genetic component, with evidence suggesting that genetics play a major role in its aetiology. While environmental factors are also involved, the evidence for a genetic basis is stronger. The study highlights that a substantial proportion of PD patients have a family history of the disease, and genetic factors are implicated in familial clustering and monogenic forms of PD. Pathogenic variants in genes such as SNCA, LRRK2, and GBA1 are strongly associated with PD, and these variants often exhibit high penetrance. In some populations, monogenic forms of PD may account for a majority of cases. Additionally, polygenic risk factors contribute to PD risk, and genome-wide association studies have identified numerous genetic loci associated with PD. The study also notes that genetic factors can influence disease progression and response to treatment. While environmental factors may play a role, they are not as significant as genetic factors in causing PD. The article concludes that genetic factors are a major contributor to PD, and further research is needed to fully understand the genetic basis of the disease and develop targeted therapies.The article argues that Parkinson's disease (PD) has a significant genetic component, with evidence suggesting that genetics play a major role in its aetiology. While environmental factors are also involved, the evidence for a genetic basis is stronger. The study highlights that a substantial proportion of PD patients have a family history of the disease, and genetic factors are implicated in familial clustering and monogenic forms of PD. Pathogenic variants in genes such as SNCA, LRRK2, and GBA1 are strongly associated with PD, and these variants often exhibit high penetrance. In some populations, monogenic forms of PD may account for a majority of cases. Additionally, polygenic risk factors contribute to PD risk, and genome-wide association studies have identified numerous genetic loci associated with PD. The study also notes that genetic factors can influence disease progression and response to treatment. While environmental factors may play a role, they are not as significant as genetic factors in causing PD. The article concludes that genetic factors are a major contributor to PD, and further research is needed to fully understand the genetic basis of the disease and develop targeted therapies.