The article "Parkinson’s Disease is Predominantly a Genetic Disease" by Shen-Yang Lim and Christine Klein argues that genetics plays a significant role in the etiology of Parkinson's disease (PD). The authors highlight multiple lines of evidence supporting a genetic basis for PD, including the identification of pathogenic variants in established PD genes and the high penetrance of certain genetic mutations. They note that while environmental factors are also important, they are not sufficient to explain the prevalence and progression of PD. The article discusses the importance of genetic testing and the development of targeted therapies based on genetic findings. It also emphasizes the need for further research on gene-environment interactions and the role of epigenetics in PD. The authors conclude that the genetic basis for PD is compelling and that efforts to reduce environmental risks and develop personalized treatments are crucial.The article "Parkinson’s Disease is Predominantly a Genetic Disease" by Shen-Yang Lim and Christine Klein argues that genetics plays a significant role in the etiology of Parkinson's disease (PD). The authors highlight multiple lines of evidence supporting a genetic basis for PD, including the identification of pathogenic variants in established PD genes and the high penetrance of certain genetic mutations. They note that while environmental factors are also important, they are not sufficient to explain the prevalence and progression of PD. The article discusses the importance of genetic testing and the development of targeted therapies based on genetic findings. It also emphasizes the need for further research on gene-environment interactions and the role of epigenetics in PD. The authors conclude that the genetic basis for PD is compelling and that efforts to reduce environmental risks and develop personalized treatments are crucial.