Pathogenic diseases influence human social behavior and cultural values. The study shows that regions with higher historical pathogen prevalence tend to have stronger collectivist values, while individualist values are more common in areas with lower pathogen prevalence. This relationship holds even after controlling for other factors like economic development and population density. Collectivist values, such as ethnocentrism and conformity, may help prevent pathogen transmission, making them more prevalent in high-pathogen areas. Conversely, individualist values may be more adaptive in low-pathogen environments. The research uses data on pathogen prevalence and cross-cultural surveys of individualism/collectivism to support this hypothesis. Results indicate strong correlations between pathogen prevalence and collectivist values, and negative correlations with individualist values. These findings suggest that pathogen prevalence significantly influences cultural values, providing a new perspective on cross-cultural differences in human societies. The study also highlights the importance of considering ecological and historical factors when understanding cultural variations.Pathogenic diseases influence human social behavior and cultural values. The study shows that regions with higher historical pathogen prevalence tend to have stronger collectivist values, while individualist values are more common in areas with lower pathogen prevalence. This relationship holds even after controlling for other factors like economic development and population density. Collectivist values, such as ethnocentrism and conformity, may help prevent pathogen transmission, making them more prevalent in high-pathogen areas. Conversely, individualist values may be more adaptive in low-pathogen environments. The research uses data on pathogen prevalence and cross-cultural surveys of individualism/collectivism to support this hypothesis. Results indicate strong correlations between pathogen prevalence and collectivist values, and negative correlations with individualist values. These findings suggest that pathogen prevalence significantly influences cultural values, providing a new perspective on cross-cultural differences in human societies. The study also highlights the importance of considering ecological and historical factors when understanding cultural variations.