February 17, 2020 | Zhe Xu, Lei Shi, Yijun Wang, Jiyuan Zhang, Lei Huang, Chao Zhang, Shuhong Liu, Peng Zhao, Hongxia Liu, Li Zhu, Yanhong Tai, Changqing Bai, Tingting Gao, Jinwen Song, Peng Xia, Jinghui Dong, Jingmin Zhao, Fu-Sheng Wang
Elsevier established a free COVID-19 resource centre in January 2020, offering information in English and Mandarin. The centre grants permission for free access to its research in PubMed Central and other repositories. A study published in Lancet Respiratory Medicine describes the pathological findings of a patient who died from severe SARS-CoV-2 infection. The patient, a 50-year-old man, had symptoms of fever, chills, cough, fatigue, and shortness of breath, and was confirmed with COVID-19. He was treated with antiviral and anti-inflammatory drugs but died due to acute respiratory distress syndrome (ARDS) caused by severe lung damage. Postmortem biopsies revealed bilateral diffuse alveolar damage, acute respiratory distress syndrome, and viral cytopathic-like changes. The liver showed microvesicular steatosis, and the heart showed no significant changes. The study highlights the similarity between COVID-19 and SARS/MERS in pathological features. Lymphopenia is a common feature in COVID-19 and may contribute to disease severity. The findings suggest that overactivation of T cells, including Th17 and cytotoxic CD8 T cells, may contribute to severe immune injury. Corticosteroid use may be beneficial for severe cases. The study provides insights into the pathogenesis of SARS-CoV-2-related pneumonia and may help in developing therapeutic strategies. The research was conducted in accordance with Chinese regulations and the Helsinki Declaration. The authors include researchers from multiple departments in Beijing. The study is supported by the National Clinical Research Center for Infectious Diseases. The findings may help in understanding the disease and improving clinical strategies. The study is part of a larger effort to understand the impact of SARS-CoV-2 on the human body. The research is published in the Lancet Respiratory Medicine journal. The study is a collaboration between multiple institutions in China. The research is supported by the National Clinical Research Center for Infectious Diseases. The study is part of a larger effort to understand the impact of SARS-CoV-2 on the human body. The research is published in the Lancet Respiratory Medicine journal. The study is a collaboration between multiple institutions in China.Elsevier established a free COVID-19 resource centre in January 2020, offering information in English and Mandarin. The centre grants permission for free access to its research in PubMed Central and other repositories. A study published in Lancet Respiratory Medicine describes the pathological findings of a patient who died from severe SARS-CoV-2 infection. The patient, a 50-year-old man, had symptoms of fever, chills, cough, fatigue, and shortness of breath, and was confirmed with COVID-19. He was treated with antiviral and anti-inflammatory drugs but died due to acute respiratory distress syndrome (ARDS) caused by severe lung damage. Postmortem biopsies revealed bilateral diffuse alveolar damage, acute respiratory distress syndrome, and viral cytopathic-like changes. The liver showed microvesicular steatosis, and the heart showed no significant changes. The study highlights the similarity between COVID-19 and SARS/MERS in pathological features. Lymphopenia is a common feature in COVID-19 and may contribute to disease severity. The findings suggest that overactivation of T cells, including Th17 and cytotoxic CD8 T cells, may contribute to severe immune injury. Corticosteroid use may be beneficial for severe cases. The study provides insights into the pathogenesis of SARS-CoV-2-related pneumonia and may help in developing therapeutic strategies. The research was conducted in accordance with Chinese regulations and the Helsinki Declaration. The authors include researchers from multiple departments in Beijing. The study is supported by the National Clinical Research Center for Infectious Diseases. The findings may help in understanding the disease and improving clinical strategies. The study is part of a larger effort to understand the impact of SARS-CoV-2 on the human body. The research is published in the Lancet Respiratory Medicine journal. The study is a collaboration between multiple institutions in China. The research is supported by the National Clinical Research Center for Infectious Diseases. The study is part of a larger effort to understand the impact of SARS-CoV-2 on the human body. The research is published in the Lancet Respiratory Medicine journal. The study is a collaboration between multiple institutions in China.