Since January 2020, Elsevier has established a COVID-19 resource center on its public news and information website, Elsevier Connect, providing free English and Mandarin information about the novel coronavirus. Elsevier has granted permission to make all COVID-19-related research available in PubMed Central and other public repositories, allowing unrestricted reuse and analysis with acknowledgment of the original source. The article also reports on the pathological findings of a 50-year-old man who died from severe COVID-19. The patient presented with fever, chills, cough, fatigue, and shortness of breath, and was confirmed to have COVID-19 on January 22, 2020. Despite treatment, his condition worsened, leading to sudden cardiac arrest and death. Postmortem biopsies revealed bilateral diffuse alveolar damage, cellular fibromyxoid exudates, and hyaline membrane formation, indicating acute respiratory distress syndrome (ARDS). The liver showed moderate microvesicular steatosis and mild lobular activity, while the heart tissue showed no significant damage. Flow cytometric analysis indicated overactivation of T cells, with increased Th17 and high cytotoxicity of CD8 T cells, contributing to severe immune injury. The study suggests that timely and appropriate use of corticosteroids and ventilator support should be considered for severe cases to prevent ARDS.Since January 2020, Elsevier has established a COVID-19 resource center on its public news and information website, Elsevier Connect, providing free English and Mandarin information about the novel coronavirus. Elsevier has granted permission to make all COVID-19-related research available in PubMed Central and other public repositories, allowing unrestricted reuse and analysis with acknowledgment of the original source. The article also reports on the pathological findings of a 50-year-old man who died from severe COVID-19. The patient presented with fever, chills, cough, fatigue, and shortness of breath, and was confirmed to have COVID-19 on January 22, 2020. Despite treatment, his condition worsened, leading to sudden cardiac arrest and death. Postmortem biopsies revealed bilateral diffuse alveolar damage, cellular fibromyxoid exudates, and hyaline membrane formation, indicating acute respiratory distress syndrome (ARDS). The liver showed moderate microvesicular steatosis and mild lobular activity, while the heart tissue showed no significant damage. Flow cytometric analysis indicated overactivation of T cells, with increased Th17 and high cytotoxicity of CD8 T cells, contributing to severe immune injury. The study suggests that timely and appropriate use of corticosteroids and ventilator support should be considered for severe cases to prevent ARDS.