This systematic review evaluates the role of patient navigation in cancer treatment, focusing on treatment initiation, adherence, quality indicators, palliative care, and patient satisfaction. A comprehensive search of PubMed and Embase databases identified 59 relevant studies published between August 1, 2009, and March 24, 2023. The findings indicate that patient navigation significantly improves treatment initiation (70%), treatment adherence (71%), patient satisfaction (87%), and quality care indicators (81%). Additionally, three palliative care studies found beneficial effects of patient navigation, and 76% of studies on disadvantaged populations reported positive impacts. Patient navigation is particularly effective for disadvantaged cancer patients, helping to reduce disparities and improve overall cancer care quality. The review highlights the importance of patient navigation in enhancing access to care and optimizing treatment outcomes. The findings support the integration of patient navigation into standard oncology practice. The review also notes that while breast cancer studies are well-represented, there is a need for more research on other cancer types. Recent policy changes, such as CMS reimbursement for patient navigation services, further support the growing recognition of patient navigation in improving cancer care. The study concludes that patient navigation plays a crucial role in improving cancer treatment outcomes and should be widely adopted to benefit more patients.This systematic review evaluates the role of patient navigation in cancer treatment, focusing on treatment initiation, adherence, quality indicators, palliative care, and patient satisfaction. A comprehensive search of PubMed and Embase databases identified 59 relevant studies published between August 1, 2009, and March 24, 2023. The findings indicate that patient navigation significantly improves treatment initiation (70%), treatment adherence (71%), patient satisfaction (87%), and quality care indicators (81%). Additionally, three palliative care studies found beneficial effects of patient navigation, and 76% of studies on disadvantaged populations reported positive impacts. Patient navigation is particularly effective for disadvantaged cancer patients, helping to reduce disparities and improve overall cancer care quality. The review highlights the importance of patient navigation in enhancing access to care and optimizing treatment outcomes. The findings support the integration of patient navigation into standard oncology practice. The review also notes that while breast cancer studies are well-represented, there is a need for more research on other cancer types. Recent policy changes, such as CMS reimbursement for patient navigation services, further support the growing recognition of patient navigation in improving cancer care. The study concludes that patient navigation plays a crucial role in improving cancer treatment outcomes and should be widely adopted to benefit more patients.