This systematic review examines the role of patient navigation in cancer treatment, focusing on its impact on treatment initiation, adherence, quality of care, patient satisfaction, and palliative care. The review includes 59 articles from PubMed and Embase databases, covering studies published between August 1, 2009, and March 27, 2023. Key findings include: - **Treatment Initiation**: 70% of studies showed a significant reduction in time to treatment initiation for patients enrolled in patient navigation programs. - **Treatment Adherence**: 71% of studies demonstrated improved treatment adherence. - **Patient Satisfaction**: 87% of studies reported high satisfaction rates with patient navigators. - **Quality of Care**: 81% of studies reported positive impacts on quality care indicators. - **Palliative Care**: Three studies highlighted beneficial effects of patient navigation in palliative care. The review also notes that 63% of the studies focused on vulnerable populations, with 76% showing positive outcomes for these groups. The findings suggest that patient navigation programs can improve access to care, optimize treatment outcomes, and reduce disparities, particularly for disadvantaged cancer patients. The review concludes that incorporating patient navigation into standard oncology practice can enhance the overall quality of cancer care.This systematic review examines the role of patient navigation in cancer treatment, focusing on its impact on treatment initiation, adherence, quality of care, patient satisfaction, and palliative care. The review includes 59 articles from PubMed and Embase databases, covering studies published between August 1, 2009, and March 27, 2023. Key findings include: - **Treatment Initiation**: 70% of studies showed a significant reduction in time to treatment initiation for patients enrolled in patient navigation programs. - **Treatment Adherence**: 71% of studies demonstrated improved treatment adherence. - **Patient Satisfaction**: 87% of studies reported high satisfaction rates with patient navigators. - **Quality of Care**: 81% of studies reported positive impacts on quality care indicators. - **Palliative Care**: Three studies highlighted beneficial effects of patient navigation in palliative care. The review also notes that 63% of the studies focused on vulnerable populations, with 76% showing positive outcomes for these groups. The findings suggest that patient navigation programs can improve access to care, optimize treatment outcomes, and reduce disparities, particularly for disadvantaged cancer patients. The review concludes that incorporating patient navigation into standard oncology practice can enhance the overall quality of cancer care.